Wenjie Gao

Guoyan Liang4
Anjing Liang4
Dongsheng Huang4
4Guoyan Liang
4Anjing Liang
4Dongsheng Huang
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BACKGROUND Adolescent idiopathic scoliosis (AIS) is one of the most common spinal deformities found in adolescent populations. Recently, a genome-wide association study (GWAS) in a Japanese population indicated that three single nucleotide polymorphisms (SNPs), rs11190870, rs625039 and rs11598564, all located near the LBX1 gene, may be associated with AIS(More)
Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported. We took a series of case-control studies, trying to understand whether Leptin gene polymorphisms are involved in the etiology of the AIS or the(More)
The collagen type II alpha 1 (COL2A1) mutation causes severe skeletal malformations, but the pathogenic mechanisms of how this occurs are unclear. To understand how this may happen, a col2a1 p.Gly1170Ser mutated mouse model was constructed and in homozygotes, the chondrodysplasia phenotype was observed. Misfolded procollagen was largely synthesized and(More)
STUDY DESIGN A retrospective study of magnetic resonance imaging of the lower lumbar spine. OBJECTIVE To describe the characteristics of the concave angle of vertebral endplate (CAVE) and study the association between CAVE and lumbar intervertebral disc degeneration (IVDD). SUMMARY OF BACKGROUND DATA The vertebral endplate is responsible for(More)
BACKGROUND Partial or total flap necrosis after flap transplantation is sometimes encountered in reconstructive surgery, often as a result of a period of hypoxia that exceeds the tolerance of the flap tissue. The purpose of this study was to determine whether Tanshinone IIA (TSA) pretreatment can protect flap tissue against hypoxic injury and improve its(More)
  • M Troyanov, J Krieger, G Crippa, Prof G Holzegel, Kressner, N Thèse +5 others
  • 2014
Whatever you do in life will be insignificant, but it is very important that you do it... Acknowledgements Foremost, I would like to express my sincere gratitude to my advisor Prof. Joachim Krieger for the continuous support of my Ph.D study and research, for his patience, motivation, enthusiasm, and immense knowledge. His guidance helped me in all the time(More)