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FK506, a secondary metabolite produced by Streptomyces tsukubaensis, is well known for its immunosuppressant properties to prevent rejection of transplanted organs and treat autoimmune diseases. However, the low titer of FK506 in the original producer strain limits the further industrialization efforts and restricts its clinical applications. To address(More)
Based on the method of mud cake to agglomerated cake (MTA), the synergism of mud cake modifier (MCM) with forming agent of agglomerated cake (FAAC) in oil and gas well is studied by means of X-ray diffraction (XRD), environmental scanning electron microscopy (ESEM) and atomic absorption spectroscopy (AAS). The results show that the mud cake with MCM at(More)
Rhizopus oryzae is strictly inhibited by biodiesel-based by-product crude glycerol, which results in low fumaric acid production. In this study, evolutionary engineering was employed to activate the glycerol utilization pathway for fumaric acid production. An evolved strain G80 was selected, which could tolerate and utilize high concentrations of crude(More)
This paper concerns the optimization of the simultaneous distillation extraction process of volatile aromatic components in flue-cured tobacco leaves by single-factor experiments and response surface methodology (RSM). The qualitative and quantitative analysis of the aroma components was performed by gas chromatography-mass spectrometry. The single-factor(More)
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