Wenji Ma

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Recently, the shared center (SC) problem has been proposed as a mathematical model for inferring the allele-sharing status of a given set of individuals using a database of confirmed haplotypes as reference. The problem was proved to be NP-complete and a ratio-2 polynomial-time approximation algorithm was designed for its minimization version (called the(More)
Linkage analysis serves as a way of finding locations of genes that cause genetic diseases. Linkage studies have facilitated the identification of several hundreds of human genes that can harbor mutations which by themselves lead to a disease phenotype. The fundamental problem in linkage analysis is to identify regions whose allele is shared by all or(More)
With the development of high-throughput methods for identifying protein-protein interactions, large scale interaction networks are available. Computational methods to analyze the networks to detect functional modules as protein complexes are becoming more important. However, most of the existing methods only make use of the protein-protein interaction(More)
Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results from aberrant expression of cardiac developmental genes. Mutations in a variety of cardiac transcription factors, developmental signalling molecules and molecules that modify chromatin cause at least 20% of disease, but most CHD remains unexplained. We(More)
Conformational changes frequently occur when proteins interact with other proteins. How to detect such changes in silico is a major problem. Existing methods for docking with conformational changes remain time-consuming, and they solve only a small portion of protein complexes accurately. This work presents a more accurate method (FlexDoBi) for docking with(More)
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