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The aim of this study was to develop sucrose ester (SE)-stabilized oleanolic acid (OA) nanosuspensions (NS) for enhanced delivery. SEOA NS were prepared via O/W emulsion and organic solvent evaporation methods. The particles’ size and polydispersity index were measured by nanosizer. Their percent encapsulation efficiency, saturation solubility and in vitro(More)
In the present study, the effect of a borneol/menthol eutectic mixture (25:75) and microemulsion on the absorption of daidzein in rat intestinal membrane was evaluated. The microemulsion formulation was composed of ethyl oleate (oil), Cremophor RH40 (surfactant), PEG400 (co-surfactant), and water. The borneol/menthol eutectic mixture and its microemulsion(More)
The effects of polyethylene glycol 20000 (PEG 20000) on the intestinal absorption of prednisolone, methylprednisolone and quinidine, three P-glycoprotein (P-gp) substrates, across the isolated rat intestinal membranes were examined by an in-vitro diffusion chamber system. The serosal-to-mucosal (secretory) transport of these P-gp substrates was greater than(More)
Young breast cancer occupies a higher and higher proportion of breast cancer, especially in Asia, and is associated with a more unfavorable prognosis compared with the disease arising in older women. However, the poor prognosis of young breast cancer cannot be fully explained by the clinical and molecular factors. This study investigated 1125 Chinese breast(More)
Flash caching has emerged as a promising solution to the scalability problems of storage systems by using fast flash memory devices as the cache for slower primary storage. But its adoption faces serious obstacles due to the limited capacity and endurance of flash devices. This paper presents CacheDedup, a solution that addresses these limitations using(More)
As most Web sites are designed for desktop PCs, it is extremely uncomfortable to browse these large pages on a mobile handheld device with small screen and limited user interface. By referring to thumbnail view concept, VIPS (vision based page segmentation) method and AJAX, which is core technology of web2.0, a dynamic Web page adaptation for mobile device(More)
OBJECTIVE Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into(More)
Mobile handheld devices, as small-screen, limited computing ability and capacity of storage, can not browse normal Web page comfortably. A new effective P2P collaborative mode for mobile Web surfing is proposed that mobile users can collaborative browse a normal rich Web page designed for PC. Firstly, a layered Web page adaptation engine is designed for the(More)
The study was designed to evaluate skin permeation enhancement effect of essential oils from Eugenia caryophyllata (clove oil) in rabbits and to compare the in vitro absorption and in vivo permeation using ibuprofen as a model drug. The in vitro results indicated a significant permeation enhancement effect of the clove oil. The group with 1% oil appeared to(More)
In mobile computing environments, as handheld devicespsila small-screen, limited computing ability and capacity of storage, consumers still experience difficulties when browsing the Web on such devices. Some researches focus on how to adapt a normal Web page to handheld device. Meanwhile, it is necessary to put existing Web adaptation engines into practice.(More)