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The Interaction of BDNF and NTRK2 Gene Increases the Susceptibility of Paranoid Schizophrenia
TLDR
The findings implied that single polymorphism of rs6265 rs1387923, rs2769605, and rs1565445 in BDNF and NTRK2 were not associated with the development of paranoid schizophrenia in a Han population, however, the interaction of BD NF and N TRK2 genes polymorphisms may be involved in the susceptibility to paranoid schizophrenia.
Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia
TLDR
Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls and a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS).
Loss of Microglia and Impaired Brain-Neurotrophic Factor Signaling Pathway in a Comorbid Model of Chronic Pain and Depression
TLDR
The results together suggest that DSS and CUS can induce the comorbidities of chronic pain and depression-like behavior.
Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy
TLDR
It is suggested that MIF may be a tractable target for reducing the metabolic side effects of atypical antipsychotic therapy and uphold the potential pharmacogenomic value of MIF genotype determination.
The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia
TLDR
The association between the interaction of TXNIP and AF1q with schizophrenia is found by using the MDR method followed by traditional statistical analysis and suggested statistically significant role of interaction ofTXNIP-rs2236566, TXNip-rs7211, and AF 1q-rs2769605 in schizophrenia susceptibility.
The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages
Rationale Animal models, notably with non-competitive NMDA receptor antagonist MK801, are commonly used to investigate the mechanisms of schizophrenia and to pursue its mechanism-related drug
A Simple Spatial Working Memory and Attention Test on Paired Symbols Shows Developmental Deficits in Schizophrenia Patients
TLDR
The data suggests that this simple Spatial Working Memory and Attention Test on Paired Symbols can be a useful tool for studies of spatial working memory and attention in neuropsychiatric disorders.