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PURPOSE To evaluate the efficacy of dose-individualized stereotactic body radiotherapy (SBRT) and adjuvant chemotherapy in stage T1-3N0M0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS Sixty-five patients with T1-3N0M0 NSCLC treated by SBRT between April 2001 and August 2005 were included. Twenty patients were CT-staged at stage T1, 34 at stage(More)
PURPOSE Pyruvate kinase isoenzyme M2 (PKM2) is a key enzyme in aerobic glycolysis; inhibition of PKM2 leads to the tumor growth inhibition. In this study, the effects of combined treatment with cisplatin (DDP) and a plasmid that expresses a short hairpin RNA (shRNA) targeting PKM2 on the growth of human A549 xenograft lung cancer model were investigated. (More)
PURPOSE Hypoxia has been found to play an important role in regulating the biological characteristics of cancer stem cells (cCSCs). In this study, we tested whether a tumor hypoxic niche serves to the chemotherapeutic resistance of colon cCSCs. METHODS Each of 23 fresh samples of human colon adenocarcinoma was transplanted into nude mice. The(More)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy to scale up. Cur-M had a small particle size of 28.2 ± 1.8 nm and polydisperse(More)
  • Zhu Yuan, Wenhao Guo, +12 authors Yuquan Wei
  • 2015
PNAS-4, a novel pro-apoptotic gene, was activated during the early response to DNA damage. Our previous study has shown that PNAS-4 induces S phase arrest and apoptosis when overexpressed in A549 lung cancer cells. However, the underlying action mechanism remains far from clear. In this work, we found that PNAS-4 expression in lung tumor tissues is(More)
We report the piezotronic effects on the photoluminescence (PL) properties of bent ZnO nanowires (NWs). We find that the piezoelectric field largely modifies the spatial distribution of the photoexcited carriers in a bent ZnO NW. This effect, together with strain-induced changes in the energy band structure due to the piezoresistive effects, results in a(More)
Chemoresistance in cancer has previously been attributed to gene mutations or deficiency. Caspase mutations or Bax deficiency can lead to resistance to cancer drugs. We recently demonstrated that Bak initiates a caspase/Bax-independent cell death pathway. We show that Plumbagin (PL) (5-hydroxy-2-methyl-1,4-napthoquinone), a medicinal plant-derived(More)
We report a remarkable improvement of photoluminescence from ZnO-core/a-SiN(x):H-shell nanorod arrays by modulating the bandgap of a-SiN(x):H shell. The a-SiN(x):H shell with a large bandgap can significantly enhance UV emission by more than 8 times compared with the uncoated ZnO nanorods. Moreover, it is found that the deep-level defect emission can be(More)
OBJECTIVE To assess the clinical and imaging features of cementoblastoma for diagnosis and differential diagnosis. METHODS Clinical and imaging data of 14 cases were selected for this retrospective study. RESULTS A total of 14 cases of cementoblastoma patients with ages at diagnosis ranging from 11 years to 58 years (mean age, 27.6 years; median age,(More)