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DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
The cell-type specific ERK1/2 response as a possible contributory factor in the neuropathological nature of Dync1h1 mutations is highlighted, despite generic aberrant kinetics in both cell types, providing an explanation for how mutations in the ubiquitously expressed DYNC1H1 cause neuron-specific disease.
Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts
A systematic survey of the dynein intermediate chain splice isoforms in mouse is undertaken, basing this study on mRNA expression patterns in a range of tissues, and on bioinformatics analysis of mouse, rat and human genomic and cDNA sequences.
Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions*
It is found that the Loa mutation in the heavy chain leads to increased affinity of this subunit of cytoplasmic dynein to light intermediate and a population of intermediate chains and a suppressed association of dynactin to Dynein.
Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression
The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1G93A Mouse Model for Motor Neuron Disease*
- A. El-Kadi, Virginie Bros-Facer, M. Hafezparast
- BiologyThe Journal of Biological Chemistry
- 9 April 2010
Evidence is provided that despite the lack of direct interactions between mutant SOD1 and either mutant or wild-type cytoplasmic dynein, the Loa mutation confers significant reductions in the amount of mutant S OD1 protein in the mitochondrial matrix, leading to improved mitochondrial function in SOD 1G93A motor neurons.
Correction: Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts
Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of eukaryotic cells and specific forms of each protein are essential for the function of different dynein complexes in neurons.
A Mixed-coding Harmony Search Algorithm for the Closed Loop Layout Problem
A Mixed-coding Harmony Search algorithm which includes Permutation-based Discrete Harmony Search (PDHS) and Continuous Harmony search (CHS) is presented, which is designed to search the optimal placement sequence of facilities and the corresponding optimal size of the rectangle loop.
WWOX Regulates UV/Cold Shock-Mediated Calcium Influx and Nuclear Bubbling in Frostbite
It is suggested that WWOX and TRAF2 dissociation is needed for nuclear bubbling and death in WWOXf cells and in hairless mice, UV/cold shock rapidly downregulated protein expression in the skin and then liver, which may lead to organ damages.