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Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis
TLDR
CIRP is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis and is upregulated in the heart and liver and released into the circulation in animal models of hemorrhage andSepsis. Expand
Current trends in inflammatory and immunomodulatory mediators in sepsis
TLDR
This review highlights the latest discoveries of the mediators in sepsis linking to innate and adaptive immune systems, which may lead to resolution of many unexplored queries. Expand
Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells.
TLDR
Overexpression of BMP-4 changed cell morphology to invasive spindle phenotype and induced the expression and activity of urokinase plasminogen activator (uPA) in colon cancer progression indicate that B MP-4 confers invasive phenotype during progression of colon cancer. Expand
Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling.
TLDR
Novel and unconventional mechanisms of cAMP and PKA signaling are reviewed to generate further enthusiasm in investigating and validating these new frontiers of the cAMP signal transduction pathway. Expand
Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia.
TLDR
Development of an anti-CIRP therapy may benefit patients with brain ischemia as it is demonstrated that hypoxia induces the expression, translocation, and release of CIRP, which is associated with an increase of TNF-α levels. Expand
Heat Shock Protein 70 Is Induced in Mouse Human Colon Tumor Xenografts After Sublethal Radiofrequency Ablation
TLDR
The data establish the requisite heat parameters during RFA for human colon tumors in vitro and in vivo and suggest HSP70 could be a potential target for enhancing the efficacy of RFA. Expand
Cold-Inducible RNA-Binding Protein Is an Important Mediator of Alcohol-Induced Brain Inflammation
TLDR
Alcohol exposure activates microglia to produce and secrete CIRP and possibly induce pro-inflammatory response and thereby causing neuroinflammation, postulate that cold-inducible RNA-binding protein (CIRP), a novel proinflammatory molecule, can contribute to alcohol-induced neuro inflammation. Expand
Milk Fat Globule-Epidermal Growth Factor-Factor 8 Attenuates Neutrophil Infiltration in Acute Lung Injury via Modulation of CXCR2
TLDR
The results of these studies clearly indicate the importance of MFG-E8 in ameliorating neutrophil infiltration and suggest MFG -E8 as a novel therapeutic potential for ALI. Expand
Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).
TLDR
It is shown here that the RIalpha subunit interacts with a BTB/POZ domain zinc-finger transcription factor, PATZ1, and co-expression with RIalpha results in its sequestration in the cytoplasm, showing a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATz1 that is independent of the kinase activity of PKA. Expand
Endoplasmic Reticulum Stress in Sepsis
TLDR
Current research in the context of ER stress and UPR signaling associated with sepsis and its related clinical conditions, such as trauma-hemorrhage and ischemia/reperfusion injury are summarized. Expand
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