Weng-I Chan

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A luminescent iridium(III) complex has been discovered to be selective for G-quadruplex DNA, and was employed in a label-free G-quadruplex-based detection assay for 3'→5' exonuclease activity in aqueous solution. A proof-of-concept of this assay has been demonstrated by using prokaryotic exonuclease III (ExoIII) as a model enzyme. In this assay, a(More)
Polymers that can activate the immune system may become useful biomaterials tools, given that the mechanisms underlying their actions are well understood. Herein, we report a novel type of interaction between polymers and immune cells - in studying the influence of the three major types of carrageenan (CGN) polysaccharides on monocyte behaviour in vitro, we(More)
The adverse effects of nanomaterials on the living system have attracted considerable attention in the past few years. Such effects may come from either the core nanomaterials or the chemical agents used to modify the nanomaterials - the latter being largely overlooked. In a free form, these modifying agents might have little impact on living cells;(More)
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