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Dietary restriction (DR) has recognized health benefits that may extend to brain. We examined how DR affects bioenergetics-relevant enzymes and signaling pathways in the brains of C57BL/6 mice. Five-month-old male mice were placed in ad libitum or one of two repeated fasting and refeeding (RFR) groups, an alternate day (intermittent fed; IF) or alternate(More)
The common way for keyword search in Distributed Hash Tables (DHTs) based Peer-to-Peer (P2P) system is to construct distributed inverted index by keywords. But it suffers from the problem of unscalable resources (e.g. bandwidth, storage) consumption. In this paper, we present SKS, a scalable keyword search approach in DHTs based P2P system. SKS introduces(More)
BACKGROUND Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor prognosis. Targeting key pathways may raise the possibility of improving clinical outcomes. METHODS The synergetic effects were assessed by CCK-8 assay and measured by isobologram analysis. The NVP-Bez235 and lenalidomide(More)
Fuzzy measure, as a non-additive metric, is an effective tool for information fusion. Constructing a determining mechanism for fuzzy measure with operability is the key focus in academic and application fields. In this paper, we first take core samples as knowledge carriers on the decision information system. According to changes of knowledge carriers, we(More)
We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage(More)
In this study, using a transposon-based strategy, two novel regulatory genes were identified as being involved in the biosynthesis of both pristinamycin I (PI) and II (PII) in Streptomyces pristinaespiralis, including a TetR-family regulatory gene atrA-p (SSDG_00466) and an orphan histidine kinase gene SSDG_02492. The mechanism by which AtrA-p exerted a(More)
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