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The model used for calculating perfusion by MRI techniques that use endogenous water as a tracer assumes that arterial water is a freely diffusible tracer. Evidence shows that this assumption is not valid in the brain at high blood flow rates, at which movement of water into and out of the microvasculature becomes limited by diffusion across the blood-brain(More)
When measuring perfusion by arterial spin labeling, saturation of tissue macromolecular spins during arterial spin labeling greatly decreases tissue water magnetization, reducing the sensitivity of the technique. In this work, a theory has been developed for perfusion measurement by arterial spin labeling without saturation of macromolecular spins. A(More)
When a single coil is used to measure perfusion by arterial spin labeling, saturation of macromolecular protons occurs during the labeling period. Induced magnetization transfer contrast (MTC) effects decrease tissue water signal intensity, reducing the sensitivity of the technique. In addition, MTC effects must be properly accounted for in acquiring a(More)
Quantitative magnetic resonance measurements of regional tissue perfusion can be obtained using magnetically labeled arterial water as a diffusable tracer. Continuous labeling is achieved in flowing spins using adiabatic inversion. The effects of continuous labeling of proximal arterial spins and T1 relaxation in distal tissue magnetization result in a(More)
In vivo NMR experiments are performed to determine the degree of spin labeling for measurement of tissue perfusion by NMR using spin labeling of arterial water by adiabatic fast passage. Arterial water spins are labeled using flow in the presence of a field gradient and B1 irradiation to fulfill the conditions for adiabatic fast passage spin inversion. It(More)
The theoretical model for perfusion measurement by NMR using arterial labeling of endogenous water is extended to include the effects of transit time and cross-relaxation of tissue water with macromolecules. Water magnetization in rat brain is monitored using the STEAM method to simultaneously determine the transit time, magnetization transfer rate(More)
Measurement of regional myocardial perfusion is important for the diagnosis and treatment of coronary artery disease. Currently used methods for the measurement of myocardial tissue perfusion are either invasive or not quantitative. Here, we demonstrate a technique for the measurement of myocardial perfusion using magnetic resonance imaging (MRI) with spin(More)
Regulatory T cells (Tregs) modulate immune responses and improve survival in murine transplant models. However, whether the Treg content of allogeneic cell grafts influences the outcome in human haematopoietic stem cell (HSC) transplantation is not well established. In a prospective study of 94 adult allogeneic PBSC transplants (60% unrelated; 85% reduced(More)
  • W Zhang
  • 1994
A theoretical analysis of the stimulated gradient-echo method for achieving T2*-preparation in magnetic resonance imaging is performed. The results show that T2*-weighting without the "shading effect" due to magnetic field variation can only be achieved if the dephasing requirement of the stimulated echo is satisfied. It is also shown that the effective(More)
PURPOSE To develop a technique for measurement of regional renal perfusion with magnetic resonance (MR) imaging. MATERIALS AND METHODS Quantitative renal perfusion images in rats were obtained by measurement of the reduction in kidney MR image signal intensity after steady state magnetic labeling of arterial blood in the suprarenal aorta. Labeling was(More)