Wendy Monk

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PURPOSE Investigate whether retinas of mice with impaired retinal cycles exposed to light or kept in the dark tolerate prolonged high-dose administration of QLT091001, which contains as an active ingredient, the 9-cis-retinal precursor, 9-cis-retinyl acetate. METHODS Four- to six-week-old Lrat(-/-) and Rpe65(-/-) mice (n = 126) as well as crossbred(More)
Absolute rate constants for the ionization of chloride from the 2-chloro-1-(4-methoxyphenyl)ethyl radical are measured in aqueous methanol and in alkali-metal cation zeolites as a function of temperature. The absolute rate constants are very fast in the two distinct media. However, the activation parameters are considerably different. In solution, the(More)
In vivo anti-nuclear antibody (ANA) was observed by direct immunofluorescence microscopy in epithelial cell nuclei in forty-four biopsies from thirty-three patients. The tissue containing the ANA was macroscopically normal in twenty-seven patients. The thirty-three patients with in vivo biopsy ANA included twenty-three with SLE, three with mixed connective(More)
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