Wendy L Kelly

Learn More
Fixation in formol-acetic-alcohol as a prelude to the staining of whole mount vertebrate skeletons with alcian blue and alizarin red S has greatly facilitated the enzyme clearing step of the method outlined by Dingerkus and Uhler. The modified method has been tested on fetal and neonatal mice, and on a variety of vertebrates including bony fish, reptiles,(More)
The behaviour of children in foster care is influenced by a variety of factors including previous experiences of maltreatment and adverse parenting, as well as the impact of separation from birth parents and placement in care. These factors make it difficult for foster parents to accurately interpret the child's behavioural cues, a necessary precursor to(More)
The coexistence of the neuropeptides substance P, cholecystokinin, somatostatin and vasoactive intestinal polypeptide in cat sensory neurons has been examined using peroxidase-anti-peroxidase immunocytochemistry. Attempts were also made to locate cells containing bombesin, neurotensin, [Met]enkephalin and [Leu]enkephalin but no immunoreactivity was found(More)
Recent data suggests that induction of prostaglandin endoperoxide H synthase-2 (PGHS-2) is critical for the anabolic response of lamellar bone elicited by mechanical strain in vivo. The aim of the present study was to localise PGHS-1 and PGHS-2 in rat tibiae following four-point bending in vivo. Right tibiae of 19 adult female rats were subjected to 300(More)
Monocyte chemotactic protein-1 (MCP-1) belongs to the CC chemokine superfamily and plays a critical role in the recruitment and activation of leukocytes during acute inflammation. We hypothesize that MCP-1 is also an important chemokine that regulates the recruitment and activation of bone cells required for skeletal repair and remodeling. We used the ulnar(More)
Epidemiological evidence and in vitro data suggest that COX-2 is a key regulator of accelerated remodeling. Accelerated states of osteoblast and osteoclast activity are regulated by prostaglandins in vitro, but experimental evidence for specific roles of cyclooxygenase-2 (COX-2) and secretory phospholipase A2 (sPLA2) in activated states of remodeling in(More)
The Lewis dwarf (DW) rat was used as a model to test the hypothesis that growth hormone (GH) is permissive for new bone formation induced by mechanical loading in vivo. Adult female Lewis DW rats aged 6.2 +/- 0.1 months (187 +/- 18 g) were allocated to four vehicle groups (DW), four GH treatment groups at 32.5 microg/100 g body mass (DWGH1), and four GH(More)
Kerr's hypothesis (J. Comp. Neurol., 159 (1975) 335-356) that chronic lesion of the lateral spinothalamic tract (LSTT) might cause the ventral STT (VSTT) to take over the nociceptive function of the LSTT was tested electrophysiologically in 4 cats. Recordings were made from 15 antidromically identified deep STT cells in L7 6 months after lesion of the LSTT(More)