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Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not(More)
Executive Summary With the substantial increase of International Baccalaureate (IB) schools across the world, the IB has recognised that support and future development of the organisation's programmes will require information relating to the impact and value of an IB education. As the science literacy of a sample of students undertaking the IB Primary Years(More)
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