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Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the deleted region is SHANK3, which encodes a(More)
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of(More)
PURPOSE Youth with chronic illness often struggle transitioning to adulthood and adult medical care. This article examines the outcomes of a group mentoring program called The Adolescent Leadership Council (TALC) that brings together high school participants and college mentors, all with chronic illness. TALC uses a positive youth development (PYD)(More)
An 8-month old girl presented to the Angkor Hospital for Children in Siem Riep, Cambodia with fevers, bilateral eye discharge and an extensive body rash. The rash consisted of large, fluid-filled bullae and significant desquamation. The patient was admitted to the hospital and given intravenous cloxacillin for presumed bullous impetigo. Despite treatment(More)
The present study was concerned with the question of whether tonic resting heart rate (HR) and resting spontaneous electrodermal activity account for the association between anticipatory HR deceleration and task performance in a choice reaction time (RT) task with a fixed foreperiod. The task employed (a varied mapping paradigm) differed from simple RT(More)
As strength of foreperiod heart rate (HR) deceleration in reaction time paradigms with a fixed foreperiod has been discussed in terms of activities related to differences in regulations of attentional processes, the present study was concerned with the question of whether this variable also accounts for the variance in the latency of response in two(More)