Wendell A. Fleming

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Peroxisomes are organelles that catabolize fatty acids and compartmentalize other oxidative metabolic processes in eukaryotes. Using a forward-genetic screen designed to recover severe peroxisome-defective mutants, we isolated a viable allele of the peroxisome biogenesis gene PEX13 with striking peroxisomal defects. The pex13-4 mutant requires an exogenous(More)
IMMUNOLOGICAL and epidemiological investigations have suggested that the multiple sclerosis (MS) reaction results from an abnormal response to a common childhood infection in individuals with a predisposing genetic con-stiution governed by the major histocompatibilitiy complex. Much effort has gone into the quest for specific infectious agents. Serological(More)
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