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UNLABELLED The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging. METHODS In a quinolinic acid-induced rat model of striatal degeneration, induced pluripotent stem cells were transplanted into the ipsilateral(More)
Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we(More)
The fast response to stimuli and subsequent activation of the nuclear factor of activated T cells (NFAT) signaling pathway play an essential role in human T cell functions. MicroRNAs (miRNAs) are increasingly implicated in regulation of numerous biological and pathological processes. In this study we demonstrate a novel function of miRNA-9 (miR-9) in(More)
An x-ray framing camera using a non-gain microchannel plate (MCP) is reported in this article. The advantage of the non-gain MCP is the less transit time spread. The non-gain MCP gated framing camera has four microstrip line cathodes with 6 mm in width. The time domain reflectometry curves of the four microstrip lines are measured, which show that the(More)
DNA vector-encoded Tough Decoy (TuD) miRNA inhibitor is attracting increased attention due to its high efficiency in miRNA suppression. The current methods used to construct TuD vectors are based on synthesizing long oligonucleotides (~90 mer), which have been costly and problematic because of mutations during synthesis. In this study, we report a PCR-based(More)
The luminance uniformity of the backlight module (BLM) importantly depends on the microstructure distribution on the bottom surface of the light guide plate (LGP). Based on the small-size integrated LGP (ILGP) proposed, we put forward a distribution expression of micro-prisms on the bottom surface of the ILGP, and present the relational expressions between(More)
There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 as one of the microRNAs induced in lungs of chronically hypoxic mice and rats. The expression of miR-322(More)
Jingqiu Chen (Corresponding author) Institute of Optoelectronics Science and Engineering Huazhong University of Science and Technology Wuhan 430074, China College of Physics Science and Technology Shenzhen University Guangdong 518060, China E-mail: chenjq@szu.edu.cn Qiao Gu International Institute of Biophysics Kaiserslautern100004, Germany Wenda Peng(More)
An eight-frame gated microchannel plate (MCP) camera and a gating electrical pulse are described in this article. The gating electrical pulse is obtained by first generating a high voltage fast step pulse using avalanche transistors in Marx bank configuration, and then shaping it using avalanche diodes. The high voltage fast step pulse is about 200 ps in(More)
The study of Z-Pinch plasma dynamics is base on space and time resolution diagnosticate. The article introduces that the principle and the configuration of a x-ray framing camera which is used on Z-pinch plasma dynamics process diagnosticate. The technology about anti-jamming and the frame pulse synchronization and delay was studied in experiments. The(More)