Wencui Zhang

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The prevalence of pathological germline mutations in colorectal cancer has been widely studied, as germline mutations in the DNA mismatch repair genes hMLH1 and hMSH2 confer a high risk of colorectal cancer. However, because the sample size and population of previous studies are very different from each other, the conclusions still remain controversial. In(More)
The purpose of this article is to comprehensively summarize the associations between carotenoids and breast cancer and quantitatively estimate their dose–response relationships. We searched PubMed, Embase, and Cochrane databases (from January 1982 to 1 May 2011) and the references of the relevant articles in English with sufficient information to estimate(More)
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal cancer (CRC). No studies to date have assessed the role of hMLH1 and hMSH2 genes in mass sporadic CRC (without preselection by MSI or early age of onset). We aimed to identify novel hMLH1 and hMSH2 DNA variants, to determine the mutation frequencies and sites(More)
BACKGROUND In 2010, the American Diabetes Association recommended the use of HbA1c as a diagnostic criterion for diabetes. However, HbA1c is not an accepted diagnostic tool for diabetes in Eastern Asia, because genetic differences compromise the standardization of the diagnostic cut-off point. OBJECTIVES This study evaluated differences in the use of(More)
As E-business developing, how to friendly and intelligently interact with users in website becomes an important issue. Because of this, the demand of semantic interoperability is expanding too. In order to enhance the collaboration and cooperation of the users and web service providers, this paper proposes a semantic based smart interactive model. The model(More)
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