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LncRNA RNCR3 promotes Chop expression by sponging miR-185-5p during MDSC differentiation
Myeloid-derived suppressor cells (MDSCs) play a critical role in regulating immune responses in cancer and other pathological conditions. Mechanism(s) regulating MDSC differentiation and function isExpand
The Pseudogene Olfr29-ps1 Promotes the Suppressive Function and Differentiation of Monocytic MDSCs
A conserved long noncoding RNA (lncRNA), pseudogene Olfr29-ps1, was identified and shown to be induced under inflammatory conditions and in melanomas. Olfr29-ps1 can regulate the immunosuppressiveExpand
Gut REG3γ-Associated Lactobacillus Induces Anti-inflammatory Macrophages to Maintain Adipose Tissue Homeostasis
Gut microbiota may not only affect composition of local immune cells but also affect systemic immune cells. However, it is not completely clear how gut microbiota modulate these immune systems. Here,Expand
Lnc-C/EBPβ Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
A long noncoding RNA, lnc-C/EBPβ, regulated the differentiation and function of myeloid-derived suppressor cells (MDSCs) and was found to also bind and inhibit C/EBPβ activation. This findingExpand
Lnc-C/EBPβ Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPβ LIP and WDR5
Myeloid-derived suppressor cells (MDSCs), which play an important role in tumor and inflammatory diseases, are divided into two subsets CD11b+Ly6ChiLy6G− monocytic MDSC (Mo-MDSC) andExpand