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Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality

• Jesús Gomeza, Koji Ohno, +5 authors Heinrich Betz
• Neuron
• 2003

The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week develop a lethal… (More)

Glycine transporters: essential regulators of neurotransmission.

• V Eulenburg, Wencke Armsen, Heinrich Betz, Jesús Gomeza
• Trends in biochemical sciences
• 2005

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the vertebrate central nervous system. The effective synaptic concentrations of glycine are regulated by… (More)

Glycine transporters: essential regulators of synaptic transmission.

• Heinrich Betz, José Manuel Gómeza, Wencke Armsen, Petra Scholze, V Eulenburg
• Biochemical Society transactions
• 2006

Glycine is a major inhibitory neurotransmitter in the mammalian CNS (central nervous system). Glycinergic neurotransmission is terminated by the uptake of glycine into glycinergic nerve terminals and… (More)

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.

• Merav Bassan, Hongguang Liu, +10 authors Paul B Rosenberg
• The European journal of neuroscience
• 2008

Synaptic plasticity is implemented by the interaction of glutamate receptors with PDZ domain proteins. Glutamate transporters provide the only known mechanism of clearance of glutamate from… (More)

Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into…

• Geraldine T Petr, Yan Sun, +12 authors Paul B Rosenberg
• The Journal of neuroscience : the official…
• 2015

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a conditional GLT-1… (More)

Lessons from the knocked-out glycine transporters.

• José Manuel Gómeza, Wencke Armsen, Heinrich Betz, V Eulenburg
• Handbook of experimental pharmacology
• 2006

Glycine has multiple neurotransmitter functions in the central nervous system (CNS). In the spinal cord and brainstem of vertebrates, it serves as a major inhibitory neurotransmitter. In addition, it… (More)

Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease.

• Geraldine T Petr, Ekaterina Bakradze, +4 authors Paul B Rosenberg
• Neurochemistry international
• 2013

Excitotoxicity may contribute to the pathogenesis of Huntington's disease. High affinity Na+ dependent glutamate transporters, residing in the plasma membrane, clear glutamate from the extracellular… (More)

Generation of a mouse line expressing Cre recombinase in glycinergic interneurons.

• Naoko Ishihara, Wencke Armsen, Theofilos Papadopoulos, Heinrich Betz, V Eulenburg
• Genesis
• 2010

In caudal regions of the CNS, glycine constitutes the major inhibitory neurotransmitter. Here, we describe a mouse line that expresses Cre recombinase under the control of a BAC transgenic glycine… (More)

The C-terminal PDZ-ligand motif of the neuronal glycine transporter GlyT2 is required for efficient synaptic localization.

• Wencke Armsen, Bettina Himmel, Heinrich Betz, V Eulenburg
• Molecular and cellular neurosciences
• 2007

The neuronal glycine transporter 2 (GlyT2) belongs to the large SLC6 family of Na+/Cl--dependent neurotransmitter transporters. At its extreme C-terminus, GlyT2 carries a type III PDZ domain binding… (More)

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