Wenchu Yang

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A method for simultaneous separation and indirect detection of anions and cations by capillary electrophoresis (CE) is reported. An anodic electroosmotic flow (EOF) in excess of -100 x 10(-9) m2 V(-1) s(-1) was achieved by the addition of 0.1 mM didodecyldimethylammonium bromide (DDAB) to the background electrolyte (BGE). This high magnitude EOF enabled(More)
AIM Evaluate the performance of ELISA microplates versus commonly used magnetic beads for biological sample cleanup and/or enrichment in immunoaffinity-LC-MS/MS to reduce tedious beads washing procedures and a relatively high assay cost. MATERIALS & METHODS ELISA microplates were used as immunicapture platform and compared with magnetic beads for sample(More)
RATIONALE A protein internal standard (IS) is essential and superior to a peptide IS to achieve reproducible results in the quantitation of protein therapeutics using immunoaffinity-liquid chromatography/tandem mass spectrometry (LC/MS/MS). Guanidination has been used as a protein post-modification technique for more than half a century. A decade ago, the(More)
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