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PURPOSE Uveal melanoma is the most common primary intraocular malignancy in adult humans. Unlike cutaneous melanoma, uveal melanoma disseminates preferentially to the liver through the hematogenous system. To date, the mechanism underlying this metastatic homing is largely unknown. This study investigated the effect of hepatocyte growth factor(More)
PURPOSE To investigate the effects of Merogel coverage on ostial patency in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic dacryocystitis (PCD). METHODS In all, 260 patients with unilateral PCD were randomized into two groups: the Merogel group and the control group. All patients underwent EES-DCR. The Merogel group received(More)
OBJECTIVE To describe a novel approach to orbital decompression for dysthyroid optic neuropathy (DON). METHODS An augmented endoscopic transethmoid medial orbital wall decompression (ETMOWD) was performed on 43 consecutive patients (72 eyes) with DON in order to access the orbital apex adequately. Concurrently, endoscopic transethmoid fat decompression(More)
BACKGROUND AND PURPOSE Myeloid differentiation 2 (MD-2) recognizes LPS, which is required for TLR4 activation, and represents an attractive therapeutic target for severe inflammatory disorders. We previously found that a chalcone derivative, L6H21, could inhibit LPS-induced overexpression of TNF-α and IL-6 in macrophages. Here, we performed a series of(More)
PURPOSE To investigate the suitability of cold steel endonasal endoscopic dacryocystorhinostomy (EES-DCR) with circular bicanalicular intubation with silicone tubes (CBIST) guided by a soft probe for the primary treatment of acute purulent dacryocystitis (APD). DESIGN Prospective, randomized, interventional case series. PARTICIPANTS Seventy-two patients(More)
PURPOSE To study the suitability of an endoscopic transcaruncular approach (ETA) for repair of large medial orbital wall fractures (MOWFs) near the orbital apex. DESIGN A retrospective, noncomparative case series with description of the surgical technique. PARTICIPANTS Ninety-three consecutive patients (93 orbits) with large isolated MOWFs near the(More)
To characterize the location of orbital blowout fractures in Asian individuals. This was a retrospective review of 470 consecutive Asian patients with orbital blowout fractures who presented to four tertiary care hospitals in Japan and China. Computed tomography (CT) characterized the location and severity of fractures involving the medial wall, the orbital(More)
deep anterior lamellar keratoplasty: prognosis. J Cataract Refract Surg 2007; 33: 825–9. 4. Shen YC, Wang CY, Tsai HY et al. Spontaneous resolution of partial donor disk dislocation after deep lamellar endothelial keratoplasty. Am J Ophthalmol 2007; 143: 358–60. 5. Tu KL, Ibrahim M, Kaye SB. Spontaneous resolution of descemet membrane detachment after deep(More)
PURPOSE To assess the combination of an endoscopic transethmoidal approach (ETEA) and a transconjunctival inferior fornix approach (TIFA) for repairing combined orbital floor and medial wall blowout fractures (COF-MWBOFs). METHODS Patients with unilateral COF-MWBOFs were randomized to 2 groups: ETEA combined with TIFA or medial canthal incision (MCI)(More)
PURPOSE To describe the surgical technique for endoscopic medial orbital fat decompression in type 1 (lipogenic) Graves orbitopathy and report outcomes. DESIGN Retrospective interventional case review. METHODS We reviewed 108 patients (206 orbits) with inactive, type 1 Graves orbitopathy without diplopia, who underwent endoscopic medial orbital fat(More)