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PURPOSE To evaluate prognostic factors for stent patency and survival in patients with perihilar cholangiocarcinoma (pCCA) who underwent percutaneous biliary stent placement. MATERIALS AND METHODS This prospective study followed 92 consecutive patients with pCCA who underwent metal stent placement between January 2013 and July 2014. Of the total number of(More)
PLGA nanoparticles simultaneously loaded with vincristine sulfate (VCR) and verapamil hydrochloride (VRP) were prepared via combining O/W emulsion solvent evaporation and salting-out method. Ten independent processing parameters and two materials characteristics were assessed systematically to enhance the incorporation of the two hydrophilic low molecular(More)
BACKGROUND/AIMS Amelioration of intestinal dysmotility and stasis during the early period of acute necrotizing pancreatitis (ANP) appears to be important to reduce the risks of secondary pancreatic infection. We aimed to characterize the association between the neuropathy of the enteric nervous system and gut dysfunction and to examine the effect of(More)
OBJECTIVES The mechanism of pain in chronic pancreatitis (CP) has yet to be explored. Proteinase-activated receptor 2 (PAR2) plays a pronociceptive role in visceral pain. The study aimed to assess the expression of PAR2 in dorsal root ganglia (DRGs) and validate its role of thermal hyperalgesia in CP. METHODS Chronic pancreatitis model was induced by(More)
Google Earth (GE) releases free images in high spatial resolution that may provide some potential for regional land use/cover mapping, especially for those regions with high heterogeneous landscapes. In order to test such practicability, the GE imagery was selected for a case study in Wuhan City to perform an object-based land use/cover classification. The(More)
This study used time-series of NDVI datasets at a spatial resolution of 8 km and 15-day interval to identify the spatial patterns of cropland phenology in China. To do so, a smoothing algorithm based on an asymmetric Gaussian function was first performed on NDVI dataset to minimize the effects of anomalous values caused by atmospheric haze and cloud(More)
AIMS The present study investigated the effects of ZnCl₂ and MnCl₂ supplementations on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction. MAIN METHODS Fluorescence detection was used to monitor the Maillard reaction. Inductively coupled plasma optical emission spectroscopy was used to test cellular zinc and(More)