Wenbiao Xian

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Parkinson’s Disease is a neurodegenerative disorder caused by multiple genetic and environmental factors. Mutations in leucinerich repeat kinase 2 (LRRK2) are the most common genetic causes for Parkinson’s disease (PD) [1]. Several LRRK2 variants including G2385R, R1628P and S1647T have been reported to increase the risk of PD among Chinese. Recently, two(More)
BACKGROUND Cognitive impairments have been reported to be common in Parkinson's disease (PD) without dementia, which occur not only in the late stages of PD, but also in the early and middle stages. Until now, no reports on the profile of cognitive impairment in Chinese non-demented PD population have been published yet. Different ethnic groups should be(More)
BACKGROUND LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson's disease (PD) in Chinese individuals. As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2. PURPOSE This study aimed to explore the effects of LRRK2 S1647T polymorphism on(More)
BACKGROUND Patients with stroke suffer from nutrition impairments and often rely on enteral nutrition (EN), which is associated with respiratory complications such as regurgitation and aspiration. OBJECTIVE To evaluate the incidence of regurgitation and aspiration in patients with severe stroke infused with different volumes of EN. METHODS A randomized(More)
To study the relationship between sleep disturbances and symptoms in patients with Parkinson’s disease (PD). The Parkinson’s Disease Sleep Scale-Chinese Version (PDSS-CV) was used to evaluate the sleep disturbances of PD patients in a cross sectional study. The Unified Parkinson’s Disease Rating Scale (UPDRS) parts II-IV, and the Hoehn & Yahr (H&Y) stage(More)
Astrocytes, which have various important functions, have previously been associated with Parkinsons disease (PD), particularly in 1-methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of PD. MPP+ is the toxic metabolite of MPTP and is generated by the enzymatic activity of monoamine oxidase B, which is(More)
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