Wen-zhen Wang

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Therapeutic numbers of antigen-specific cytotoxic T lymphocytes (CTLs) are key effectors in successful adoptive immunotherapy. However, efficient and reproducible methods to meet the qualification remain poor. To address this issue, we designed the artificial antigen-presenting cell (aAPC) system based on poly(lactic-co-glycolic acid) (PLGA). A modified(More)
Recent studies have indicated that telomerase activity promotes cancer invasion and metastasis, but the underlying mechanism remains unclear. Several studies have shown that expression of exogenous human telomerase reverse transcriptase (hTERT) can promote motility and invasiveness among telomerase-negative tumor cells, and inhibition of endogenous(More)
Six new pyrazine-modulated N,N'-bis(alpha-pyridyl)-2,6-diaminopyridine ligands (PMN5) were synthesized and their complexes studied. Reaction of copper(II) with the ligand that contained one pyrazine ring in its terminal position led to formation of a one-dimensional zigzag complex whereas copper(II) reactions with ligands containing three pyrazine rings or(More)
Here we designed and synthesized a new ligand, di(2-pyrazyl)amine (Hdpza) (1) and studied its coordination modes and the corresponding complexes with Cu(II), Co(II), Ni(II) and Cr(II). Hdpza is an analogue of the well-studied di(2-pyridyl)amine (Hdpa) ligand, which was used to generate the first extended metal atom chain. Three types of coordination modes(More)
The influence of sample temperature on the wheat PLS near infrared (NIR) quantitative analysis was studied with 45 wheat seeds. The original spectra of the wheat seeds were measured at different temperatures. The temperature corrections were subtracted from the original spectra of the samples by using the PLS algorithm. The corrected spectra were used to(More)
Two pentacobalt(II) EMACs were synthesized. A pyrazine-modulated tripyridyldiamine resulted in an EMAC with fully delocalized Co-Co bonds along molecules. From a pyrazine- and naphthyridine-containing ligand, a defective cobalt linear EMAC with an 8-coordinated cobalt(II) in the center was obtained for the first time. An electrochemistry study on the(More)
The excited-state dynamics of Ni(3)(dpa)(4)X(2), in which dpa is the ligand di(2-pyridyl)amido and X = NCS or Cl, are investigated by transient absorption spectroscopy. The pi pi* and dd states are excited upon irradiation at wavelengths of 330 and 600 nm, respectively. Similar transient spectra are observed under the experimental temporal resolution. The(More)
To design new metal string complexes, several naphthyridyl group modulated oligo-alpha-pyridylamido ligands have been synthesized in the past five years. Because these ligands are less anionic than pyridylamido ligands, the resulting metal string complexes tend to form reduced mixed-valence [Ni(2)(napy)(4)](3+) dinuclear units which contain a delocalized(More)