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Identification of Functional Mutations in GATA4 in Patients with Congenital Heart Disease
Congenital heart disease (CHD) is one of the most prevalent developmental anomalies and the leading cause of noninfectious morbidity and mortality in newborns. Despite its prevalence and clinicalExpand
Functional Variant in Methionine Synthase Reductase Intron-1 Significantly Increases the Risk of Congenital Heart Disease in the Han Chinese Population
Background— Homocysteine is known to be an independent risk factor for congenital heart disease (CHD). Methionine synthase reductase (MTRR) is essential for the adequate remethylation ofExpand
Meta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancer
PurposeMatrix metalloproteinases (MMPs) play important roles in pathogenesis and development of cancer. Recently, lots of studies showed that there were associations between polymorphisms in theExpand
MiR-10a and MiR-10b Target the 3′-Untranslated Region of TBX5 to Repress Its Expression
Abstract As a well-known transcription factor, TBX5 is involved in embryonic cardiac development. Although TBX5 functions in a dose-dependent manner, the posttranscriptional regulation of human TBX5Expand
Genome-wide copy number variant analysis for congenital ventricular septal defects in Chinese Han population
BackgroundVentricular septal defects (VSDs) constitute the most prevalent congenital heart disease (CHD), occurs either in isolation (isolated VSD) or in combination with other cardiac defectsExpand
Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis
To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted a meta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphismExpand
Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations.
AIMS Elevated homocysteine levels are known to be a risk factor for congenital heart disease (CHD), but the mechanism underlying this effect is unknown. During early embryonic development,Expand
Genetic Polymorphisms of the TYMS Gene Are Not Associated with Congenital Cardiac Septal Defects in a Han Chinese Population
Background Clinical research indicates that periconceptional administration of folic acid can reduce the occurrence of congenital cardiac septal defects (CCSDs). The vital roles of folate exhibits inExpand
Susceptibility to congenital heart defects associated with a polymorphism in TBX2 3′ untranslated region in the Han Chinese population
BackgroundTbx2 plays a critical role in determining fates of cardiomyocytes. Little is known about the contribution of TBX2 3′ untranslated region (UTR) variants to the risk of congenital heartExpand
Association of Two Variants in SMAD7 with the Risk of Congenital Heart Disease in the Han Chinese Population
SMAD7 is a general antagonist of TGF-β signaling and has been found to be involved in cardiogenesis in mouse models, but its role in human congenital heart disease (CHD) has yet to be investigated.Expand
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