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Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues

A cytoplastic expression pattern of APMCF1 is revealed and up-regulated in tumour tissues suggesting APMCf1 may have potential relationship with oncogenesis and might provide a potential anti-tumor target.
Springer (opens in a new tab)

Expression of NDRG2 in human lung cancer and its correlation with prognosis

The data showed that NDRG2 may play an important role in human lung cancer tumourigenesis, and NDRg2 might serve as a novel prognostic marker inhuman lung cancer.
Springer (opens in a new tab)

Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21

Results of cell cycle gene chips analysis showed up-regulation of p21 expression and down- regulation of TIMP3 in HHCC cells expressing ectogenic APMCF1, indicating that APMCf1 participates at least partially in cell cycle regulation through regulating genes such as p21 and TIMP 3.
Springer (opens in a new tab)

[The construction and expression of a hepatocellular carcinoma-specific superantigen SEA (D227A) expression vector].

The successful construction and expression of hepatocellular carcinoma-specific superantigen SEA (D227A) gene expression vector lay the foundation for enhancing immunotherapy of hepatic carcinoma.
PubMed (opens in a new tab)

[Inhibitory effect of tumor suppressor gene PTEN on hepatocellular carcinoma cell line HHCC proliferation and its mechanisms of action].

Wild type PTEN gene can inhibit the proliferation of hepatocellular carcinoma cells at G(1) phase, and the mechanism is possibly related with intrinsic activity of AKT, which is down-regulated by wildtype PTEN.
PubMed (opens in a new tab)

Superantigen-SEA gene modified tumor vaccine for hepatocellular carcinoma: an in vitro study.

Tumor cell membrane expressed superantigen can be used to reinforce the immune effect of tumor cell vaccine for HCC, which provides a new method of the enhanced active immunotherapy for H CC.
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[Mutations of tumor suppressor gene PTEN mutations in hepatocellular carcinoma and its implications in tumor proliferation and apoptosis].

PTEN inhibition of the proliferation and the enhancement of apoptosis of hepatocellular carcinoma cells is likely related to a down-regulation of the TNF-alpha induced activation of protein kinase Akt pathway.
PubMed (opens in a new tab)

Knockdown of survivin gene expression by RNAi induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721.

RNAi can exert a knockdown of survivin gene expression in SMMC-7721 cells, and induce apoptosis and inhibit the growth of carcinoma cells.
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Construction of a regulable gene therapy vector targeting for hepatocellular carcinoma.

This recombinant expression vector can be used as a gene therapy vector for HCC and the expression of tumor killing gene will be confined within the site of tumor and the activity of which can be regulated by retinoic acid.
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[Apoptosis induced by curcumin and its effect on c-myc and caspase-3 expressions in human melanoma A375 cell line].

Curcumin can inhibit the proliferation and induce apoptosis of A375 cells in vitro, and the genes encoding c-myc and caspase-3 may play a role in the process.
PubMed (opens in a new tab)
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