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Using NGF heparin-poloxamer thermosensitive hydrogels to enhance the nerve regeneration for spinal cord injury.
OBJECTIVE Nerve growth factor (NGF) has potential in spinal cord injury (SCI) therapy, but limited by the poor physicochemical stability and low ability to cross the blood spinal cord barrier. Novel… Expand
Advanced Interfere Treatment of Diabetic Cardiomyopathy Rats by aFGF-Loaded Heparin-Modified Microbubbles and UTMD Technique
This study aims to investigate the preclinical performance and mechanism of a novel strategy of aFGF-loaded heparin-modified microbubbles (aFGF-HMB) combined with ultrasound-targeted microbubble… Expand
Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats
Purpose Intranasal administration of phospholipid-based gelatin nanoparticles (GNP) was prepared to investigate the neuro-recovery effects of neuropeptide Substance P (SP) on hemiparkinsonian rats.… Expand
Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction.
- Yingzheng Zhao, Xin-qiao Tian, +14 authors H. L. Wong
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 July 2014
Diabetic cardiomyopathy (DCM) is the leading cause of morbidity and mortality among the diabetic patients and currently there is no effective means to reverse its pathological progress. Basic… Expand
Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study
Background The aim of this study was to investigate the protective role of intranasally administered substance P-loaded gelatin nanoparticles (SP-GNPs) against 6-hydroxydopamine (6-OHDA)-induced… Expand
Delivery of growth factor‐based therapeutics in vascular diseases: Challenges and strategies
Either cardiovascular or peripheral vascular diseases have become the major cause of morbidity and mortality worldwide. Recently, growth factors therapeutics, whatever administrated in form of… Expand
Using FUS induced BBB/BTB-opening technique combined with Doxorubicin liposomes to improve glioma-targeted inhibition
// Ying-Zheng Zhao 1, 2, 3 , Li-Juan Chen 4 , Qian Lin 1 , Jun Cai 5 , Wen-Ze Yu 1 , Ya-Ping Zhao 2 , Chong-Yong Xu 2 , Kai-Li Mao 1 , Fu-Rong Tian 1 , Wen-Feng Li 6 , Ho Lun Wong 7 , Cui-Tao Lu 1, 2… Expand
Grinding wheel condition monitoring based on neural network