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Carboxymethyl- and carboxyl-catechins from ripe Pu-er tea.
Ripe Pu-er tea, a special microbial postfermented tea originated from Yunnan Province, China, since ancient times, is made from green Pu-er tea prepared from the leaves of Camellia sinensis var.
Schisphenlignans A-E: five new dibenzocyclooctadiene lignans from Schisandra sphenanthera.
Five new dibenzocyclooctadiene lignans, schisphenlignans A-E (1-5), together with eight known ones, were isolated from the stems of Schisandra sphenanthera. The structures of 1-5 were elucidated
Five New Nortriterpenoids from the Stems of Schisandra neglecta
TLDR
Five new nortriterpenoids, schicagenins D-F (1-3, resp.) and negleschidilactones A and B (4 and 5, resp.), together with eleven known ones, were isolated from the stems of Schisandra neglecta on the basis of extensive spectroscopic analyses.
Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa
TLDR
Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
Steaming Changes the Composition of Saponins of Panax notoginseng (Burk.) F.H. Chen That Function in Treatment of Hyperlipidemia and Obesity.
TLDR
Interestingly, N-PNS demonstrated promising activities in improving hyperlipidemia and reducing body weight and weight of white adipose tissue and the inhibition of adipogenesis in obese mice and it was demonstrated that the activity may involve the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway by promoting phosphorylation of AMPKT172 and downregulating its downstream factors.
Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents
TLDR
A structure-based lead optimization of vibralactone resulted in three series of 104 analogs, among which compound C1 exhibited the most potent inhibition of pancreatic lipase, with an IC50 value of 14 nM, more than 3000-fold higher than that of vibRALactone.
Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile
TLDR
The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.
Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest
TLDR
It is reported that eriocalyxin B blunted adipogenesis remarkably by inhibiting the accumulation of lipid droplets, triglycerides and the expressions of adipogenesis-related factors, including C/EBPβ, C/ EBPα, PPARγ, and FABP4.
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