Wen Tan

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A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

Tong Sun, Yang Gao, +9 authors Dongxin Lin
Nature Genetics
2007

Caspases are important in the life and death of immune cells and therefore influence immune surveillance of malignancies. We tested whether genetic variants in CASP8, CASP10 and CFLAR, three genes… (More)

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

Zhibin Hu, Chen Wu, +42 authors Hongbing Shen
Nature Genetics
2011

Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a genome-wide… (More)

Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.

Xuemei Zhang, Xiaoping Miao, +10 authors Dongxin Lin
Gastroenterology
2005

BACKGROUND & AIMS Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 promoter might contribute to… (More)

Unified Tuning of PID Load Frequency Controller for Power Systems via IMC

Wen Tan
IEEE Transactions on Power Systems
2010

A unified PID tuning method for load frequency control (LFC) of power systems is discussed in this paper. The tuning method is based on the two-degree-of-freedom (TDF) internal model control (IMC)… (More)

Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.

Tong Sun, Yifeng Zhou, +11 authors Dongxin Lin
Cancer research
2008

Antitumor T lymphocytes play a pivotal role in immunosurveillance of malignancy. The CTL antigen 4 (CTLA-4) is a vital negative regulator of T-cell activation and proliferation. This study examined… (More)

Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.

Xuemei Zhang, Xiaoping Miao, +5 authors Dongxin Lin
Human mutation
2006

The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is… (More)

Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.

Bingtao Hao, Haijian Wang, +9 authors Fuchu He
Cancer research
2004

The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are… (More)

Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis.

Jian Xu, Chen Wu, +8 authors Dongxin Lin
Molecular carcinogenesis
2011

Numerous studies have shown that aberrant microRNA (miRNA) expression is associated with the development and progression of various types of human cancer and serum miRNAs are potential biomarkers.… (More)

Analysis and control of a nonlinear boiler-turbine unit

Wen Tan, Horacio J. Marquez, Tongwen Chen, Jizhen Liu
2005

A distance measure is proposed via the gap metric in this paper, and the concept is applied to a boiler-turbine unit to analyze its dynamics. It is shown that the unit shows severe nonlinearity, but… (More)

Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population.

Chunjiao Song, Deyin Xing, Wen Tan, Qingyi Wei, Dongxin Lin
Cancer research
2001

Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis. Because germ-line mutations at nucleotides 677 (C-->T) and 1298… (More)

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