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Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung(More)
The Internet has recently been evolving from homogeneous congestion control to heterogeneous congestion control. Several years ago, Internet traffic was mainly controlled by the traditional RENO, whereas it is now controlled by multiple different TCP algorithms, such as RENO, CUBIC, and Compound TCP (CTCP). However, there is very little work on the(More)
RFID (radio frequency identification) technologies are poised to revolutionize retail, warehouse and supply chain management. One of their interesting applications is to automatically detect missing tags (and the associated objects) in a large storage space. In order to timely catch any missing event such as theft, the detection operation may have to be(More)
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to UV-induced p53-dependent apoptosis by interacting with, and phosphorylating Ser 46 of, p53. In addition to association with p53 via HIPK2, Axin contains a separate(More)
The use and quality of longitudinal research designs has increased over the past two decades, and new approaches for analyzing longitudinal data, including multi-level modeling (MLM) and latent growth modeling (LGM), have been developed. The purpose of this paper is to demonstrate the use of MLM and its advantages in analyzing longitudinal data. Data from a(More)
The Wnt/beta-catenin signaling pathway is critical in both cellular proliferation and organismal development. However, how the beta-catenin degradation complex is inhibited upon Wnt activation remains unclear. Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive(More)
Sonazoid (Daiichi Sankyo, Tokyo, Japan), a second-generation of a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent, has been used clinically in patients with liver tumors and for harmonic gray-scale ultrasonography (US) in Japan since January 2007. Sonazoid-enhanced US has two phases of contrast enhancement: vascular and late.(More)
—RFID tags have many important applications in automated warehouse management. One example is to monitor a set of tags and detect whether some tags are missing — the objects to which the missing tags are attached are likely to be missing, too, due to theft or administrative error. Prior research on this problem has primarily focused on efficient protocols(More)
Cross-classified random-effects models (CCREMs) are used for modeling nonhierarchical multilevel data. Misspecifying CCREMs as hierarchical linear models (i.e., treating the cross-classified data as strictly hierarchical by ignoring one of the crossed factors) causes biases in the variance component estimates, which in turn, results in biased estimation in(More)