Wen-Lien Lin

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OBJECTIVES The present study aimed to explore the role of microribonucleic acid (miRNA) Let-7g in regulating endothelial functions. BACKGROUND Derangement of miRNAs is implicated in the pathogenesis of cardiovascular diseases. Because the transforming growth factor (TGF)-β pathway plays a regulatory role in endothelial functions, miRNAs targeted at TGF-β(More)
DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR)-dependent phosphorylation of Chk2 and Chk1 kinases, which are hallmarks of the DNA damage response (DDR). Pharmacologic inhibition of ATR causes a synthetic lethal effect on ATM- or p53-defective cancers, suggesting that such(More)
Hui-Chun Wang, Alan Yueh-Luen Lee, Wen-Cheng Chou, Chih-Chung Wu, Chao-Neng Tseng, Kevin Yen-Ting Liu, Wen-Lien Lin, Fang-Rong Chang, Da-Wei Chuang, Attila Hunyadi, Yang-Chang Wu Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung(More)
DNAdamage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) andATMandRad3-related (ATR)-dependentphosphorylation ofChk2andChk1kinases,which arehallmarks of theDNAdamage response (DDR). Pharmacologic inhibition ofATR causes a synthetic lethal effect onATMorp53-defective cancers, suggesting that such inhibition is an(More)
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