Wen Jun Yin

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MicroRNAs (miRNAs) are a group of small RNAs with a fundamental role in the regulation of gene expression. These RNAs have been shown to participate in various cellular and physiological processes, including cellular development, apoptosis, proliferation, and differentiation. Aberrant expression of several miRNAs was found to be involved in a large variety(More)
Elevation of serum homocysteine (Hcy) levels is a risk factor for cardiovascular diseases. Previous studies suggested that Hcy interferes with copper (Cu) metabolism in vascular endothelial cells. The present study was undertaken to test the hypothesis that Hcy-induced disturbance of Cu homeostasis leads to endothelial cell injury. Exposure of human(More)
It is critical for retail enterprises to select good sites or locations to open their stores, especially in current competitive retail market. However, evaluating the goodness of sites in real business applications is a complex problem. That is, how to judge whether the market around a store site is good? We don't know the exact mechanism of how a site can(More)
Recently, paeoniflorin (PF) administered systemically was found to have analgesic effects against inflammatory pain and hypersensitivity in a naloxone-reversible manner. In the present study, we adopted intrathecal administration to evaluate whether PF has direct antinociceptive actions at the spinal level. Pain-related behaviors and spinal c-Fos expression(More)
In this paper, we consider the optimization of service rates in queueing systems, especially in closed Jackson networks. The optimization criterion is the customer-average performance, which is another important performance metric compared with the traditional time-average performance. Based on the methodology of perturbation analysis, we can derive a(More)
In this paper, we consider a general problem of semi-supervised preference learning, in which we assume that we have the information of the extreme cases and some ordered constraints, our goal is to learn the unknown preferences of the other places. Taking the potential housing place selection problem as an example, we have many candidate places together(More)