Wen-Fu Lee

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In this study, we developed a nanoparticle system for drug delivery across the blood-brain barrier (BBB). The nanoparticle consisting of loperamide and poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer were prepared by the nanoprecipitation method; then the nanoparticles were coated with poloxamer(More)
BACKGROUND AND PURPOSE Macular edema is an important cause of visual loss in various retinal diseases, and may be refractory to conventional treatment. We investigated the efficacy of intravitreal injection of triamcinolone acetonide for the treatment of intractable macular edema. METHODS A prospective study was conducted in 17 patients (18 eyes) with a(More)
Visual attention, which is an important characteristic of human visual system, is a useful clue for image processing and compression applications in the real world. This paper proposes a computational scheme that adopts both low-level and high-level features to predict visual attention from video signal by machine learning. The adoption of low-level(More)
A series of organic hybrid gels were prepared based on poly(N-isopropylacrylamide), poly(NIPAAm), and gelatin. The hybrid gels were crosslinked through a two-step process with genipin or glutaraldehyde. The swelling behavior and physical properties of the gels were investigated in the previous report. In this study, we loaded sulfanilamide, caffeine,(More)
It is often required to map the radiances of a real scene to a smaller dynamic range so that the image can be properly displayed. However, most such algorithms suffer from the halo artifact or require manual parameter tweaking that is often a tedious process for the user. We propose an automatic algorithm for high dynamic range compression based on the(More)
A series of amphiphilic random block co-polymers were synthesized by the condensation of hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy poly(ethylene glycol) (PEG-diacid), obtained by reacting poly(ethylene glycol) (PEG) with succinic anhydride. The PEG/PCL random block co-polymers were then acrylated with acryloyl chloride to form(More)
This study evaluates the sustained analgesic effect of ketorolac-eluting thermosensitive biodegradable hydrogel in the plantar incisional pain model of the rat hind-paw. A ketorolac-embedded 2, 2'-Bis (2-oxazolin) (BOX) linking methoxy-poly(ethylene glycol) and poly(lactide-co-glycolide) (mPEG-PLGA) diblock copolymer (BOX copolymer) was synthesized as(More)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter(More)
A new computational scheme for visual attention modeling is proposed. It adopts both low-level and high-level features to predict visual attention from a video signal and fuses the features by using machine learning. We show that such a scheme is more robust than those using purely single level features. Unlike conventional techniques, our scheme is able to(More)
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