Wen-Feng Liaw

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The synthesis, characterization, and transformation of the anionic {Fe(NO)(2)}(9) dinitrosyl iron complexes (DNICs) [(NO)(2)Fe(ONO)(2)](-) (1), [(NO)(2)Fe(OPh)(2)](-) (2), [(NO)(2)Fe(OPh)(C(3)H(3)N(2))](-) (3) (C(3)H(3)N(2) = imidazolate), [(NO)(2)Fe(OPh)(-SC(4)H(3)S)](-) (4), [(NO)(2)Fe(p-OPhF)(2)](-) (5), and [(NO)(2)Fe(SPh)(ONO)](-) (6) were(More)
In addition to probing the formation of dinitrosyl iron complexes (DNICs) by the characteristic Fe K-edge pre-edge absorption energy ranging from 7113.4 to 7113.8 eV, the distinct S K-edge pre-edge absorption energy and pattern can serve as an efficient tool to unambiguously characterize and discriminate mononuclear DNICs and dinuclear DNICs containing(More)
The reversible redox transformations [(NO)(2)Fe(S(t)Bu)(2)](-) ⇌ [Fe(μ-S(t)Bu)(NO)(2)](2)(2-) ⇌ [Fe(μ-S(t)Bu)(NO)(2)](2)(-) ⇌ [Fe(μ-S(t)Bu)(NO)(2)](2) and [cation][(NO)(2)Fe(SEt)(2)] ⇌ [cation](2)[(NO)(2)Fe(SEt)(2)] (cation = K(+)-18-crown-6 ether) are demonstrated. The countercation of the {Fe(NO)(2)}(9) dinitrosyliron complexes (DNICs) functions to(More)
In contrast to the four-coordinate tetrahedral {Fe(NO)2}9 DNICs with an EPR g value of 2.03, the newly synthesized nonclassical six-coordinate {Fe(NO)2}9 DNIC [(1-MeIm)2(eta(2)-ONO)Fe(NO)2] (1-MeIm = 1-methylimidazole) (1) displays an EPR signal g = 2.013. The temperature-dependent reversible transformation occurs between the six-coordinate chelating(More)
Spontaneous transformation of the thermally stable [HS](-)-bound {Fe(NO)2}(9) dinitrosyl iron complex (DNIC) [(HS)2Fe(NO)2](-) (1) into [(NO)2Fe(μ-S)]2(2-) (Roussin's red salt (RRS)) along with release of H2S, probed by NBD-SCN (NBD = nitrobenzofurazan), was observed when DNIC 1 was dissolved in water at ambient temperature. The reversible transformation of(More)
Nitrosylation of high-spin [Fe(κ(2)-O(2)NO)(4)](2-) (1) yields {Fe(NO)}(7) mononitrosyl iron complex (MNIC) [(κ(2)-O(2)NO)(κ(1)-ONO(2))(3)Fe(NO)](2-) (2) displaying an S = 3/2 axial electron paramagnetic resonance (EPR) spectrum (g(⊥) = 3.988 and g(∥) = 2.000). The thermally unstable nitrate-containing {Fe(NO)(2)}(9) dinitrosyl iron complex (DNIC)(More)
Nitric oxide (NO) is an important cellular signaling molecule that modulates various physiological activities. Angiogenesis-promoting activities of NO-donor drugs have been explored in both experimental and clinical studies. In this study, a structurally well characterized and water-soluble neutral {Fe(NO)2}(9) DNIC [(S(CH2)2OH)(S(CH2)2NH3)Fe(NO)2] (DNIC 2)(More)
Transformations of dinitrosyl iron complex (DNIC) [(NO)(2)Fe(SEt)(2)](-) and the anionic Roussin's red ester (RRE) [(NO)(2)Fe(mu-SEt)(2)Fe(NO)(2)](-) into [2Fe-2S] clusters facilitated by HSCPh(3)/Me(2)S(3) and [Fe(SEt)(4)](-), respectively, via an intermediate anionic mixed thiolate-sulfide-bridged RRE [(NO)(2)Fe(mu-SEt)(mu-S)Fe(NO)(2)](-) through the(More)
The neutral trinuclear iron-thiolate-nitrosyl, [(ON)Fe(mu-S,S-C(6)H(4))](3) (1), and its oxidation product, [(ON)Fe(mu-S,S-C(6)H(4))](3)[PF(6)] (2), were synthesized and characterized by IR, X-ray diffraction, X-ray absorption, electron paramagnetic resonance (EPR), and magnetic measurement. The five-coordinated, square pyramidal geometry around each iron(More)
This manuscript describes the interaction of low-molecular-weight DNICs with short peptides designed to explore the stability and structure of DNIC-peptide/RRE-peptide constructs. Although characterization of protein-bound and low-molecular-weight DNICs is possible via EPR, XAS, and NRVS, this study demonstrates that the combination of aqueous IR ν(NO) and(More)