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Genetic characterisation of linezolid-resistant Gram-positive cocci in a multicentre study in China has not been reported previously. To study the mechanism underlying the resistance of linezolid-resistant isolates, nine Enterococcus faecalis, one Enterococcus faecium and three Staphylococcus cohnii isolates with various levels of resistance were collected(More)
BACKGROUND The prevalence of carbapenem-resistant Acinetobacter baumannii in hospitals has been increasing worldwide. This study aims to investigate the carbapenemase genes and the clonal relatedness among A. baumannii clinical isolates in a Chinese hospital. METHODS Carbapenemase genes and the upstream locations of insertion sequences were detected by(More)
Typhoid and paratyphoid fever are endemic in China. The objective of this investigation was to determine the molecular features of nalidixic acid-resistant Salmonella enteric serovar Typhi (S. typhi) and Paratyphi (S. paratyphi) from blood isolates in Shenzhen, China. Twenty-five S. typhi and 66 S. paratyphi were isolated from 91 bacteriemic patients(More)
The prevalence of extended-spectrum beta-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae, and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 beta-lactamase (pI 8.6). A(More)
OBJECTIVE To investigate the clinical features, mechanism of resistance and molecular epidemiology of carbapenem-resistant Acinetobacter baumannii (CRAB) infections at Shenzhen People's Hospital during an 8-year period. METHODS A. baumannii isolates were recovered from nosocomial infections patients at this hospital from 2002 to 2009. The minimum(More)
engineering design processes. Among these models, one of the most widely known is perhaps the one proposed by Pahl and Beitz [42]. It presents a systematic engineering design approach including four core design phases: product planning and clarifying the task, conceptual design, embodiment design, and detail design. Similarly, Ulrich and Eppinger [43](More)
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