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Lysosomal storage diseases (LSDs) are a group of heterogeneous disorders caused by defects in lysosomal enzymes or transporters, resulting in accumulation of undegraded macromolecules or metabolites. Macrophage numbers are expanded in several LSDs, leading to histiocytosis of unknown pathophysiology. Here, we found that mice lacking the equilibrative(More)
Zarrin Wenjun Ouyang, Flavius Martin, Wyne P. Lee and Ali A. Balazs, Tao Sai, Benjamin Haley, Philip E. Hass, Min Xu, Mariathasan, Jason DeVoss, Shahram Misaghi, Mercedesz Sophie Lehar, Vida Asghari, WeiYu Lin, Sanjeev Rio, Lu, Zhonghua Lin, Kai Barck, Judy Young, Mariela Del Lesch, Ivan Peng, Andrew Sebrell, Wilman Luk, Yanmei Sarah Kummerfeld, Gabriel(More)
OBJECTIVE To determine whether a combination of B cell depletion and BAFF blockade is more effective than monotherapy in treating models of spontaneous or accelerated systemic lupus erythematosus (SLE) in (NZB × NZW)F1 mice. METHODS Clinical parameters such as disease progression-free survival, proteinuria, and renal injury were assessed in models of(More)
Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during(More)
Fungal Cu-thioneins, and among them, the paradigmatic Neurospora crassa metallothionein (MT) (26 residues), were once considered as the shortest MTs--the ubiquitous, versatile metal-binding proteins--among all organisms, and thus representatives of their primeval forms. Nowadays, fungal MTs of diverse lengths and sequence features are known, following the(More)
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