Weiyao Zou

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We have developed a new, unified implementation of the adaptive optics scanning laser ophthalmoscope (AOSLO) incorporating a wide-field line-scanning ophthalmoscope (LSO) and a closed-loop optical retinal tracker. AOSLO raster scans are deflected by the integrated tracking mirrors so that direct AOSLO stabilization is automatic during tracking. The(More)
We implemented a Lagrange-multiplier (LM)-based damped least-squares (DLS) control algorithm in a woofer-tweeter dual deformable-mirror (DM) adaptive optics scanning laser ophthalmoscope (AOSLO). The algorithm uses data from a single Shack-Hartmann wavefront sensor to simultaneously correct large-amplitude low-order aberrations by a woofer DM and(More)
We constructed a high speed and high-resolution Stokes vector retinal imaging polarimeter with dual electro-optical modulators based on adaptive optics scanning laser ophthalmoscope. By varying the voltages on the EO crystals line by line, we were able to measure over 500,000 Stokes vectors per second. We used this system in three human subjects(More)
An iterative zonal wave-front estimation algorithm for slope or gradient-type data in optical testing acquired with regular or irregular pupil shapes is presented. In the mathematical model proposed, the optical surface, or wave-front shape estimation, which may have any pupil shape or size, shares a predefined wave-front estimation matrix that we(More)
In this paper, a wavefront curvature sensor is presented. This sensor is based on the measurements of the differentials of wavefront slopes, where the wavefront slope measurements can be achieved by a Shack-Hartmann sensor. A Shack-Hartmann sensor with three output collimated beams will be introduced with a lenslet array installed in each beam. By shifting(More)
An ophthalmic adaptive optics (AO) imaging system is especially affected by pupil edge effects due to the higher noise and aberration level at the edge of the human pupil as well as the impact of head and eye motions on the pupil. In this paper, a two-step approach was proposed and implemented for reducing the edge effects and improving wavefront slope(More)
The concept of a differential Shack-Hartmann (DSH) curvature sensor was recently proposed, which yields wavefront curvatures by measuring wavefront slope differentials. As an important feature of the DSH curvature sensor, the wavefront twist curvature terms can be efficiently obtained from slope differential measurements, thus providing a means to measure(More)
We discuss error propagation in the slope-based and the difference-based wavefront estimations. The error propagation coefficient can be expressed as a function of the eigenvalues of the wavefront-estimation-related matrices, and we establish such functions for each of the basic geometries with the serial numbering scheme with which a square sampling grid(More)
We propose a multiple estimation adjustment (MEA) method to correct effect overestimation due to selection bias from a hypothesis-generating study (HGS) in pharmacogenetics. MEA uses a hierarchical Bayesian approach to model individual effect estimates from maximal likelihood estimation (MLE) in a region jointly and shrinks them toward the regional effect.(More)
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