Weixia Zhang

Learn More
The objective of this study is to investigate the correlation between methods of high-performance liquid chromatography (HPLC) and enzyme multiplied immunoassay technology (EMIT) for determination of total mycophenolic acid (tMPA) and free (fMPA) concentration and to study pharmacokinetics of fMPA in Chinese liver transplant recipients. An HPLC method with(More)
To establish the population pharmacokinetic (PPK) model of cyclosporine (CsA) in Chinese renal transplant recipients and evaluate the influence of various indexes including CYP3A5 and MDR1 genetic polymorphism on pharmacokinetic parameters. Trough (C0) and peak (C2) CsA concentration were monitored conventionally after renal transplantation. C0 and C2 were(More)
C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1) gene have substantial impact on expression or activity of P-glycoprotein (P-gp). We developed new methods based on amplification refractory mutation system (ARMS) to detect these polymorphisms. Tetra-primers amplification in a single tube was established to detect C1236T and C3435T(More)
Mycophenolate Mofetil (MMF) is widely used in preventing acute rejection in liver transplantation. Only free MPA (fMPA) can exert the pharmacological effect. In this study, we aimed to develop the new model which could be best fit to predict the fMPA area under the plasma concentration-time curve (AUC) by limited sampling strategy (LSS) in Chinese liver(More)
A surfactant containing a terminal carbon source moiety was synthesized and used simultaneously as both template molecule and carbon source. On the basis of this special structure-directing agent, an efficient strategy for producing uniform carbon nanowires with diameter below 1 nm was developed using a confined self-assembly approach. Besides the(More)
The integration of 3D-ordered macropores with poly(ionic liquid)s can significantly extend the functions of poly(ionic liquid)s, and afford a new type of material, which can serve as not only tunable photonic crystals and anion-directed molecular gating system, but also as a surface with enhanced tunable wettability and unique stable electro-optic switching.
Nanostructures with precise control of sizes and shapes, intrinsic read-out signals for tracking, and flexible surface chemistry for bioconjugation can offer an excellent system to study interaction between nanomaterials and cells. In this paper, a new nanobio system based on functionalized silicon nanowires (SiNWs) was developed. Using the intensive and(More)