Weiwei Wu

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Unpredictable natural disasters and human interventions could pose significant threats to the undersea cables of modern telecommunication networks. In this paper, we consider the network topology of the undersea cables and propose a rectangular network to prevent all the cable links from being damaged simultaneously. An optimization problem on the plane is(More)
PURPOSE The objectives of this research were to assess the biocompatibility of self-assembled Fe(3)O(4) magnetic nanoparticles (MNPs) loaded with daunorubicin (DNR), ie, (Fe(3)O(4)-MNPs/DNR), and to explore their potential application in the treatment of hematologic malignancies. METHODS A hemolysis test was carried out to estimate the hematologic(More)
BACKGROUND Multidrug resistance in cancer is a major obstacle for clinical therapeutics, and is the reason for 90% of treatment failures. This study investigated the efficiency of novel multifunctional Fe(3)O(4) magnetic nanoparticles (Fe(3)O(4)-MNP) combined with chemotherapy and hyperthermia for overcoming multidrug resistance in an in vivo model of(More)
Gambogic acid (GA) has a significant anticancer effect on a wide variety of solid tumors. Recently, many nanoparticles have been introduced as drug-delivery systems to enhance the efficiency of anticancer drug delivery. The aim of this study was to investigate the potential benefit of combination therapy with GA and magnetic nanoparticles of Fe(3)O(4)(More)
This study aims to evaluate the multidrug resistance (MDR) reversal activity by magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) and 5-bromotetrandrine (BrTet) MDR cell line K562/A02 solitarily or symphysially. The proliferation of K562 and K562/A02 cells and the cytotoxicity on peripheral blood mononuclear cells (PMBCs) were evaluated by MTT assay. Cellular(More)
This paper investigates rate scheduling problems for an energy-harvesting enabled wireless transmitter to optimally transmit a set of dynamically arrived packets to a receiver. We take into account individual packet transmission delay constraints, which is key to guaranteeing per-application quality-of-service (QoS), and consider the discrete-rate(More)
Dynamic voltage scaling technique provides the capability for processors to adjust the speed and control the energy consumption. We study the pessimistic accelerate model where the acceleration rate of the processor speed is at most K and jobs cannot be executed during the speed transition period. The objective is to find a min-energy (optimal) schedule(More)
—Survivability is one of the most important requirements in design of communications networks, since we as a society are increasingly relying on the Internet, and service interruptions are very costly. Unfortunately, submarine fibre-optic networks are vulnerable to unpredictable disasters, such as earthquakes or nuclear explosions, which pose significant(More)
Stromal fibrosis and tissue necrosis are major histological sequelae of hypoxia. The hypoxia-to-fibrosis sequence is well-documented in pancreatic ductal adenocarcinoma (PDAC). However, hypoxic and necrotic PDAC phenotypes are insufficiently characterized. Recently, reduction of tuberous sclerosis expression in mice together with oncogenic Kras demonstrated(More)
OBJECTIVE Functional neuroimaging techniques act as the navigator to assess changes in brain activity induced by repetitive transcranial magnetic stimulation (rTMS) in rTMS studies. The aim of this study was to investigate the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to measure the brain activity in rTMS studies. METHODS(More)