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A marine actinomycete, designated strain BM-17, was isolated from a sediment sample collected in the Arctic Ocean. The strain was identified as Nocardia dassonvillei based on morphological, cultural, physiological, biochemical characteristics, along with the cell wall analysis and 16S rDNA gene sequence analysis. A new secondary metabolite (1),(More)
Lung cancer is one of the most death-related cancers worldwide. Ursolic acid (UA), a pentacyclic triterpene acid, has a wide range of anticancer functions such as proapoptosis, antiangiogenesis, and antimetastasis. This study was carried out to explore the inhibition mechanism of UA on metastasis of lung cancer A549 cells. First, we found that UA inhibited(More)
BACKGROUND AND AIMS Angiopoietin-like protein 2 (Angptl2) is regarded as a proinflammatory factor in the pathogenesis of atherosclerosis and is expressed at high levels in patients with coronary artery disease. However, direct evidence of Angptl2 in acute coronary syndrome (ACS) is lacking. Our study was designed to investigate a possible relationship(More)
MicroRNAs are endogenously expressed small, non-coding RNAs that modulate biological processes by recognizing specific gene transcripts, leading to translational repression or degradation. Previous work showed that the miR-17-92 cluster is highly expressed in human endothelial cells that participate in angiogenesis. In this study we showed that miR-19b-1, a(More)
Ht-2 is a novel oxaliplatin derivative previously identified in a compound screen performed by our laboratory. In the present study, we evaluated the antitumor effects of Ht-2 and investigated its underlying mechanism of action. Ht-2 exhibited anti-tumor activity and demonstrated low cytotoxicity in normal cells in vitro. The IC50 of Ht-2 was 2–10-fold(More)
This study investigated electrochemical detection of human hepatitis B and papilloma viruses using electrochemical impedance spectroscopy technique. The sensor was fabricated by electrochemically depositing Au nanoparticles on the in situ prepared single walled carbon nanotube (SWCNTs) arrays, followed by the self-assembly of single-stranded probe DNA on(More)
The interests of Location Based Services (LBS) have been highly increased according to the development of location aware techniques and mobile devices. Various spatial-indexing methods based on R-tree structure have been proposed to process queries efficiently. However, many node accesses occur in tree based spatial index structures when queries are(More)
This paper choose financial date in 2010, including 132 listed companies in Zhejiang province and 44 listed companies in Liaoning province which went public in Shanghai and Shenzhen exchange before 2010. Through statistics software spss 16.0, using least square method of multiple regression analysis with goodness-of-fit R2 inspection, whole F test of(More)