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MicroRNAs are endogenously expressed small, non-coding RNAs that modulate biological processes by recognizing specific gene transcripts, leading to translational repression or degradation. Previous work showed that the miR-17-92 cluster is highly expressed in human endothelial cells that participate in angiogenesis. In this study we showed that miR-19b-1, a(More)
BACKGROUND AND AIMS Angiopoietin-like protein 2 (Angptl2) is regarded as a proinflammatory factor in the pathogenesis of atherosclerosis and is expressed at high levels in patients with coronary artery disease. However, direct evidence of Angptl2 in acute coronary syndrome (ACS) is lacking. Our study was designed to investigate a possible relationship(More)
A marine actinomycete, designated strain BM-17, was isolated from a sediment sample collected in the Arctic Ocean. The strain was identified as Nocardia dassonvillei based on morphological, cultural, physiological, biochemical characteristics, along with the cell wall analysis and 16S rDNA gene sequence analysis. A new secondary metabolite (1),(More)
Ht-2 is a novel oxaliplatin derivative previously identified in a compound screen performed by our laboratory. In the present study, we evaluated the antitumor effects of Ht-2 and investigated its underlying mechanism of action. Ht-2 exhibited anti-tumor activity and demonstrated low cytotoxicity in normal cells in vitro. The IC50 of Ht-2 was 2–10-fold(More)
Lung cancer is one of the most death-related cancers worldwide. Ursolic acid (UA), a pentacyclic triterpene acid, has a wide range of anticancer functions such as proapoptosis, antiangiogenesis, and antimetastasis. This study was carried out to explore the inhibition mechanism of UA on metastasis of lung cancer A549 cells. First, we found that UA inhibited(More)
The interests of Location Based Services (LBS) have been highly increased according to the development of location aware techniques and mobile devices. Various spatial-indexing methods based on R-tree structure have been proposed to process queries efficiently. However, many node accesses occur in tree based spatial index structures when queries are(More)
The effects of humic acid (HA) on the solubility and biodegradability of mixed polycyclic aromatic hydrocarbons (PAHs) (phenanthrene (PHE), pyrene (PYR), and benzo[a]pyrene (BAP)) in liquid media and mangrove sediment slurries were investigated. The addition of HA to the liquid media (0-1.6%, w/v) significantly enhanced the solubility of all mixed three(More)
This study investigated electrochemical detection of human hepatitis B and papilloma viruses using electrochemical impedance spectroscopy technique. The sensor was fabricated by electrochemically depositing Au nanoparticles on the in situ prepared single walled carbon nanotube (SWCNTs) arrays, followed by the self-assembly of single-stranded probe DNA on(More)
OBJECTIVE To study the effect of chromomycin A(2) in inducing apoptosis of HepG2 cells and explore the molecular mechanism. METHODS HepG2, MCF-7, A549, and 7901 cells were exposed to chromomycin A(2) and the changes in the cell viability were detected using MTT assay. The changes in the chromatins were observed with laser scanning confocal microscope(More)