• Publications
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LncACTdb 2.0: an updated database of experimentally supported ceRNA interactions curated from low- and high-throughput experiments
  • P. Wang, Xin Li, +12 authors Xia Li
  • Computer Science, Medicine
  • Nucleic Acids Res.
  • 22 November 2018
TLDR
LncACTdb 2.0 is a continually updated database which provides comprehensive information of competing endogenous RNAs (ceRNAs) in different species and diseases and will serve as an important resource to explore ceRNAs in physiological and pathological processes. Expand
A novel method to quantify gene set functional association based on gene ontology
  • Sali Lv, Y. Li, +8 authors Xia Li
  • Biology, Medicine
  • Journal of The Royal Society Interface
  • 7 May 2012
TLDR
Improved the measurement of semantic similarity to quantify the functional association between gene sets in the context of gene ontology and developed a web toolkit named Gene Set Functional Similarity (GSFS), which shows better discrimination and more accurately reflects the known functional catalogues shared between complexes. Expand
A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells.
TLDR
The underlying mechanism of CDDP resistance is revealed, and novel potential drug targets and therapeutics for CDDP-resistant ovarian cancer patients are provided. Expand
Identification of (-)-epigallocatechin-3-gallate as a potential agent for blocking infection by grass carp reovirus
TLDR
The results suggest that EGCG is a promising compound that may be developed as a plant-derived small molecular therapeutic agent against grass carp hemorrhagic disease caused by GCRV infection. Expand
Community of protein complexes impacts disease association
TLDR
A human disease network is built in which two diseases are linked if they share common disease-related protein complex, and that the stronger association two diseases have based on protein complexes, the higher comorbidity they are prone to display. Expand
Disruption of clathrin-dependent trafficking results in the failure of grass carp reovirus cellular entry
TLDR
The findings suggest that GCRV might enter CIK cells via clathrin-mediated endocytosis in a pH-dependent manner and that dynamin is critical for efficient viral entry. Expand
Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus
TLDR
The data have suggested that GCRV104 enters CIK cells through clathrin-mediated endocytosis in a pH-dependent manner, and it is suggested that dynamin is critical for efficient viral entry. Expand
Grass carp Ctenopharyngodon idella Fibulin-4 as a potential interacting partner for grass carp reovirus outer capsid proteins.
TLDR
The results suggested that Fibulin-4 might enable free GCRV particles, the pathogen for grass carp hemorrhagic disease, to target fish tissues more efficiently by interacting with viral outer capsid proteins. Expand
Grass carp reovirus outer capsid proteins VP5 and VP7 interact in vitro
TLDR
It is shown that VP5 and VP7 interact directly in vitro, and a yeast-two-hybrid approach confirmed interactions between full-length and truncated forms ofVP5 andVP7. Expand