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Tenzing is a query engine built on top of MapReduce [9] for ad hoc analysis of Google data. Tenzing supports a mostly complete SQL implementation (with several extensions) combined with several key characteristics such as het-erogeneity, high performance, scalability, reliability, meta-data awareness, low latency, support for columnar storage and structured(More)
Postoperative cognitive decline is a clinical concern especially for senior patients. It is generally recognized that glutamatergic system plays a crucial role in the physiopathologic process of neurocognitive deterioration. However, alterations of glutamatergic system in prolonged isoflurane-induced learning/memory decline are still unclear. This study(More)
Some anesthetics have been suggested to induce Alzheimer’s disease (AD) neuro-pathogenesis. Increasing evidence indicates that hyperphosphorylated tau plays a key role in the pathogenic events that occur in AD. Isoflurane has been shown to induce apoptosis, which leads to accumulation of amyloid-β (Aβ). We set out to investigate whether isoflurane can(More)
OBJECTIVES The molecular mechanism of postoperative cognitive dysfunction is largely unknown. Isoflurane has been shown to promote Alzheimer's disease neuropathogenesis. We set out to determine whether the effect of isoflurane on spatial memory is associated with amyloid-beta (A-beta) levels and tau phosphorylation in aged rats. METHODS Eighteen-month-old(More)
Recent studies hypothesized that phospholipids stabilize two voltage-sensing arginine residues of certain voltage-gated potassium channels in activated conformations. It remains unclear how lipids directly affect these channels. Here, by examining the conformations of the KvAP in different lipids, we showed that without voltage change, the voltage-sensor(More)
We focus on practical Hierarchical Identity-Based Broadcast Encryption (HIBBE) with semantic security against adaptively chosen-ciphertext attacks (CCA2) in the standard model. We achieve this goal in two steps. First, we propose a new HIBBE scheme that is secure against chosen-plaintext attacks (CPA). Compared with the existing HIBBE scheme that is built(More)
Electronic health network (EHN) is an information system providing functions involved in e-health. In this paper, we devise mechanisms covering three important security and privacy issues of EHN including trust management, privacy preserving, and data sharing. First, we propose an authenticated key agreement scheme based on hierarchical identity-based(More)