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OBJECTIVES To investigate the use of oral anticoagulants (AC) and antiplatelet agents (AP) in the management of atrial fibrillation (AF) among patients in primary care in England. DESIGN Epidemiological study. SETTING 1857 general practices in England representing a practice population of 13.1 million registered patients. PATIENTS 231,833 patients(More)
Antral-pyloric strictures and gastric outlet obstruction are known complications of caustic ingestions. These lesions can develop even in the absence of overt signs of potentially serious upper gastrointestinal tract pathology such as oropharyngeal burns, dysphagia, vomiting, or abdominal pain at the time of ingestion. The development of radial balloon(More)
AIMS To prospectively investigate the relation between cannabis use expectancies and cannabis use prior to and during a self-initiated cannabis cessation attempt. DESIGN Cohort design that followed participants for 4 weeks following a self-initiated cessation attempt. SETTING United States Department of Veterans Affairs medical center. PARTICIPANTS(More)
BACKGROUND Hospital acute myocardial infarction (AMI) care is increasingly evaluated using composite quality scores. We investigated the influence of three aggregation methods for an AMI indicator on mortality and hospital rank. METHODS AND RESULTS We studied 136,392 patients discharged alive from 199 hospitals with AMI recorded in the Myocardial(More)
Apolipoprotein E (ApoE) is a factor involved in Alzheimer’s disease, which recently attracted great attention as an important protein related to tumorigenesis and metastasis. However, serum ApoE levels and its diagnosis and prognosis value in non-small cell lung cancer (NSCLC) patients are still unknown. In 196 NSCLC patients and 203 healthy controls, serum(More)
AIMS Aortic valve surgery in the presence of reduced ejection fraction (EF) or low transaortic gradient is associated with adverse outcome. Low gradient (LG) may be associated with reduced EF, known as low EF-low gradient (LEF-LG), or "paradoxically" low with normal EF (P-LG). Our aim was to investigate the impact of EF and transaortic gradient on outcome(More)
The Budget Method, originally developed for determining food additive use limits, has been proposed as a tool for screening food additive intakes to establish monitoring priorities. Theoretical Maximum Daily Intake (TMDI) estimates derived using the Budget Method rely on assumptions regarding physiological requirements for energy and liquid and on the(More)
BACKGROUND Though a growing number of US Veterans are being diagnosed with cannabis use disorders, with posttraumatic stress disorder (PTSD) observed as the most frequently co-occurring psychiatric disorder among this population, no research has investigated the impact of PTSD diagnosis on cannabis quit success. OBJECTIVES The present study sought to(More)