Weiqin Zheng

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The topology of folded proteins from the representative dataset of well-defined three-dimensional protein structures is studied using a statistical geometry approach. Amino acid residues in protein chains are represented by C alpha atoms, thus reducing the protein three-dimensional structure to a set of points in three dimensional space. The Delaunay(More)
Combinatorial library design is by nature a multicriterion problem. These criteria often include reagent diversity, product similarity to lead compounds and product novelty with respect to a corporate compound bank. More recently, developability and druglikeness have also attracted much attention in library design practices. To address this multicriterion(More)
Distributed generation (DG) systems are integral parts in future distribution networks. In this paper, a novel approach integrating crisscross optimization algorithm and Monte Carlo simulation (CSO-MCS) is implemented to solve the optimal DG allocation (ODGA) problem. The feature of applying CSO to address the ODGA problem lies in three interacting(More)
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