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Green tea polyphenol (GTP) is one of the most promising chemopreventive agent for cancer; it can inhibit cancer cell proliferation and induce apoptosis through p53-dependent cell signaling pathways. Unfortunately, many tumor cells lack the functional p53, and little is known about the effect of GTP on the p53-deficient/mutant cancer cells. To understand the(More)
The aim of the present study was to determine the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and diethyldithiocarbamate (DDTC) alone or in combination on human pancreatic cancer cells cultured in vitro and grown as xenograft tumors in nude mice. Pancreatic cancer cells were treated with either DDTC or TPA alone, or in combination and the number(More)
Developing a recombinant vector for noninvasively delivering biological macromolecules into the brain is important. This study constructed and purified a protein complex based on the cholera toxin (CT) molecular structure. Enhanced green fluorescent protein (EGFP)-modified A2 subunits of CT (CTA2) were used as tracer molecules for introduction of(More)
Goal We hope to develop fibers that change character or regulate performance in a desirable manner when the surrounding environment changes. Recent progress in intelligent stimuli-sensitive polymers gives optimism that fibers can be made which self-regulate structure and performance in response to environmental variation. We plan to develop fibers from(More)
According to the characteristics of OCT images for macula edema, we studied a method for segmentation of the macula edema. Based on the Chan-Vese model, we proposed an improved level-set algorithm. With defining the integer-valued signed function directly, the curve could evolute outward or inward by changing the inside neighboring rid points and outside(More)
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