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Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associated breast cancers have lower levels of SIRT1 than their normal controls. We further demonstrated that mammary tumors from Brca1 mutant mice have low levels of(More)
Berberine shows anticancer, antibacterial, antiinflammatory and antioxidant effects and may be useful in many clinical applications. The effects of berberine on articular cartilage metabolism remain unknown, so this study was performed to evaluate these effects in vitro and in vivo. For the in vitro work, rat articular chondrocytes were cultured in a(More)
PURPOSE Although( 18)F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in(More)
We studied the source, concentration, spatial distribution and health risk of 16 polycyclic aromatic hydrocarbons (PAHs) in urban soils of Beijing. The total mass concentration of 16 PAHs ranged from 93 to 13,141 μg kg(-1) with a mean of 1228 μg kg(-1). The contour map of soil PAH concentrations showed that the industrial zone, the historical Hutong(More)
BACKGROUND & AIMS Polymorphisms in the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection. Little is known about the function of type III IFNs in intrinsic antiviral innate immunity. METHODS We used in vivo and in vitro models to characterize the role of the type(More)
Agarwood is the fragrant resin-infused wood derived from the wounded trees of Aquilaria species. It is a valuable non-timber forest product used in fragrances and as medicine. Reforestation for Aquilaria trees in combination with artificial agarwood-inducing methods serves as a way to supply agarwood and conserve of wild Aquilaria stock. However, the(More)
BACKGROUND Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death in cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug approved for treatment of multiple myeloma and Mantle cell(More)
Astaxanthin is a red carotenoid pigment which exerts multiple biological activities. However, little is known about the effects of astaxanthin on matrix metalloproteinases (MMPs) in OA. The present study investigated the effects of astaxanthin on MMPs in human chondrocytes. Human chondrocytes were pretreated with astaxanthin at 1, 10 or 50μM, then, cells(More)
UNLABELLED The aim of this study was to compare optimized voxel-based morphometry (VBM) and (18)F-FDG PET for discrimination between patients with Alzheimer's disease (AD) and healthy subjects in relation to age. METHODS The study population consisted of 2 groups; the first group (27 AD patients and 40 control subjects) was used to determine the locations(More)
Studies have shown that physical and chemical properties of soils may be significantly changed when they are subjected to long-term reclaimed water irrigation. It remains unclear how reclaimed water application may affect nutrient cycling in soils. Soil enzymes are responsible for the biogeochemical cycling of many elements and are more sensitive indicators(More)