Learn More
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. HSP90 is a ubiquitous protein that is commonly overexpressed in cancer cells where it is required to promote the proper folding of several oncoproteins. Without its chaperoning presence, these proteins are ubiquitylated and degraded, hence inhibiting HSP90(More)
PURPOSE HSP90 is a chaperone protein required for the stability of a variety of client proteins. 17-Demethoxygeldanamycin (17-AAG) is a natural product that binds to HSP90 and inhibits its activity, thereby inducing the degradation of these clients. In preclinical studies, HER2 is one of the most sensitive known client proteins of 17-AAG. On the basis of(More)
Glioblastoma is the most common and most aggressive malignant primary brain tumor in humans, accounting for 52 % of all functional tissue brain tumor cases and 20 % of all intracranial tumors. The typical treatment involves a combination of chemotherapy, radiation, and surgery, whereas it still achieves fairly poor patient survival. Ginsenoside Rh2 has been(More)
Medulloblastomas (MBs) are the most common malignant brain tumor in children. The current therapeutic strategies are ineffective against the infiltrative and disseminative nature of MBs in about one-third of patients. Based on studies which have revealed the tumor-tropic characteristic of neural stem cells (NSCs), we used an immortalized neural stem cell(More)
The malignancy of glioblastoma multiforme (GBM) is largely due to its local invasion and the presence of the tumor in the relatively restrained region in the brain. Hence, effective prevention of the cancer cell invasion is substantially critical for controlling the growth and deterioration of GBM. We have recently reported the role of ginsenoside Rh2(More)
Considering the characteristics of the propagation of worm, we can analyze it by epidemic model. In this paper, considering that to re-assembly system and the use of anti-virus software will take a period of time, so we introduce a time-delay to describe this period of time. On this basis, we build a SIDRQ model for Internet worm virus propagation depended(More)
Purpose. To assess if there is a significant difference in enhancement of high grade serous carcinoma of the ovary compared with other ovarian malignancies on clinically performed contrast enhanced MRI studies. Methods. In this institutional-review-board-approved study, two radiologists reviewed contrast enhanced MRI scans in 37 patients with ovarian(More)
  • 1