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MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from
It is concluded that MYC/BCL2 coexpression in DLBCL is associated with an aggressive clinical course, is more common in the ABC subtype, and contributes to the overall inferior prognosis of patients with ABC-DLBCL.
Human immunodeficiency virus‐associated plasmablastic lymphoma
The authors conducted a multi‐institutional, retrospective study to describe characteristics and determine prognostic factors in HIV‐associated PBL.
Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature.
Following chemotherapy, complete remission and long-term survival were achieved in a subset of patients, as was particularly true for 2 patients, with complete remission 12.5 and 31 years after diagnosis, respectively.
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
A metabolomics method for the analysis of rare cell populations isolated directly from tissues is described and used to compare mouse haematopoietic stem cells (HSCs) to restricted haematography-like progenitors, finding ascorbate accumulates within HSCs to promote Tet activity in vivo, limiting HSC frequency and suppressing leukaemogenesis.
IDH mutations in acute myeloid leukemia.
Exposure of IDH1/2 mutants induces an increase in global DNA hypermethylation and inhibits TET2-induced cytosine 5-hydroxymethylation, DNA demethylation and the epigenetic state, an important consideration for the development of therapeutic agents.
Prenatal stress causes gender‐dependent neuronal loss and oxidative stress in rat hippocampus
The data suggest that prenatal stress can cause oxidative stress and consequent damage to neurons, leading to neuronal loss in the brain of offspring during development.
Immunophenotypic study of basophils by multiparameter flow cytometry.
Flow cytometric immunophenotypes can identify immunophenotypic aberrations of basophils in chronic myelogenous leukemia, and discriminate basophil from myeloblasts.
Consensus guidelines on plasma cell myeloma minimal residual disease analysis and reporting
Major heterogeneity between laboratories in flow cytometry (FC) minimal residual disease (MRD) testing in multiple myeloma (MM) must be overcome. Cytometry societies such as the International
Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience.
Flow cytometry is suitable for the detection of residual B-ALL, provided that follow-up studies are not too narrowly targeted, and new aberrancies were detected in 60% of cases.
Prognostic Factors of Hepatosplenic T-cell Lymphoma: Clinicopathologic Study of 28 Cases
The data presented support the novel suggestions that HSTCL patients can be stratified into 2 prognostic groups, with an elevated serum bilirubin level, TCR expression, and trisomy 8 identifying a poorer prognostic group.