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Quinazoline 3 was discovered as a novel c-jun N-terminal kinase (JNK) inhibitor with good brain penetration and pharmacokinetic (PK) properties. A number of analogs which were potent both in the biochemical and cellular assays were discovered. Quinazoline 13a was found to be a potent JNK3 inhibitor (IC(50)=40 nM), with >500-fold selectivity over p38, and(More)
A genomic database consists of a set of nucleotide sequences , for which an important kind of queries is the local sequence alignment. This paper investigates two different indexing techniques, namely the variations of GNAT trees [1] and M-trees [3], to support fast query evaluation for local alignment, by transforming the alignment problem to a variant(More)
We present a novel technique for multiple-dispatching. In object-oriented programming languages, multiple-dispatching provides increased expressive power over single-dispatching by guiding method lookup using the values of all arguments instead of the receiver only. However, the efficient implementation for multiple-dispatching is still critical with regard(More)
beta-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity, despite being generally thought of as simple Mendelian diseases. The reasons for this are not well understood, although the level of fetal hemoglobin (HbF) is one well characterized ameliorating factor in both of these conditions. To better understand the genetic(More)
Dosimetry verification is an important step during intensity modulated radiotherapy treatment (IMRT). The verification is usually conducted with measurements and independent dose calculations. However, currently available independent dose calculation methods were developed for step-and-shoot beam delivery methods, and their uses for dynamic multi-leaf(More)